Cell Receptor-Basement Membrane Interactions in Health and Disease: A Kidney-Centric View

Overview

Journal Curr Top Membr

Specialties Biochemistry
Cell Biology

Date 2015 Nov 28

PMID 26610916

Citations 10

Authors

Corina M Borza

Xiwu Chen

Roy Zent

Ambra Pozzi

Affiliations

Soon will be listed here.

Abstract

Cell-extracellular matrix (ECM) interactions are essential for tissue development, homeostasis, and response to injury. Basement membranes (BMs) are specialized ECMs that separate epithelial or endothelial cells from stromal components and interact with cells via cellular receptors, including integrins and discoidin domain receptors. Disruption of cell-BM interactions due to either injury or genetic defects in either the ECM components or cellular receptors often lead to irreversible tissue injury and loss of organ function. Animal models that lack specific BM components or receptors either globally or in selective tissues have been used to help with our understanding of the molecular mechanisms whereby cell-BM interactions regulate organ function in physiological and pathological conditions. We review recently published works on animal models that explore how cell-BM interactions regulate kidney homeostasis in both health and disease.

Citing Articles

Integrins in the kidney - beyond the matrix.

Bock F, Li S, Pozzi A, Zent R Nat Rev Nephrol. 2024; 21(3):157-174.

PMID: 39643697 DOI: 10.1038/s41581-024-00906-1.

Spatially Resolved Transcriptomes of Mammalian Kidneys Illustrate the Molecular Complexity and Interactions of Functional Nephron Segments.

Raghubar A, Pham D, Tan X, Grice L, Crawford J, Lam P Front Med (Lausanne). 2022; 9:873923.

PMID: 35872784 PMC: 9300864. DOI: 10.3389/fmed.2022.873923.

DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.

Borza C, Bolas G, Bock F, Zhang X, Akabogu F, Zhang M JCI Insight. 2021; 7(3.

PMID: 34941574 PMC: 8855801. DOI: 10.1172/jci.insight.150887.

Renal Biology Driven Macro- and Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies.

Vermue I, Begum R, Castilho M, Rookmaaker M, Masereeuw R, Bouten C ACS Biomater Sci Eng. 2021; 7(10):4679-4693.

PMID: 34490771 PMC: 8512683. DOI: 10.1021/acsbiomaterials.1c00408.

Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study.

Clotet-Freixas S, McEvoy C, Batruch I, Pastrello C, Kotlyar M, Van J J Am Soc Nephrol. 2020; 31(11):2705-2724.

PMID: 32900843 PMC: 7608967. DOI: 10.1681/ASN.2020030286.

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