Recent Advances in BLV Research

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2015 Nov 28

PMID 26610551

Citations 46

Authors

Pierre-Yves Barez

Alix de Brogniez

Alexandre Carpentier

Helene Gazon

Nicolas Gillet

Geronimo Gutierrez

Malik Hamaidia

Jean-Rock Jacques

Srikanth Perike

Sathya Neelature Sriramareddy

Nathalie Renotte

Bernard Staumont

Michal Reichert

Karina Trono

Luc Willems

Affiliations

Soon will be listed here.

Abstract

Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.

Citing Articles

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Molecular frequency of bovine leukemia virus in Creole cattle of Eastern Colombia.

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References

Meas S, Ohashi K, Tum S, Chhin M, Te K, Miura K . Seroprevalence of bovine immunodeficiency virus and bovine leukemia virus in draught animals in Cambodia. J Vet Med Sci. 2000; 62(7):779-81. DOI: 10.1292/jvms.62.779. View

Gutierrez G, Rodriguez S, de Brogniez A, Gillet N, Golime R, Burny A . Vaccination against δ-retroviruses: the bovine leukemia virus paradigm. Viruses. 2014; 6(6):2416-27. PMC: 4074934. DOI: 10.3390/v6062416. View

Merezak C, Pierreux C, Adam E, Lemaigre F, Rousseau G, Calomme C . Suboptimal enhancer sequences are required for efficient bovine leukemia virus propagation in vivo: implications for viral latency. J Virol. 2001; 75(15):6977-88. PMC: 114426. DOI: 10.1128/JVI.75.15.6977-6988.2001. View

Lefebvre L, Vanderplasschen A, Ciminale V, Heremans H, Dangoisse O, Jauniaux J . Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase. J Virol. 2002; 76(3):1400-14. PMC: 135811. DOI: 10.1128/jvi.76.3.1400-1414.2002. View

Debacq C, Asquith B, Kerkhofs P, Portetelle D, Burny A, Kettmann R . Increased cell proliferation, but not reduced cell death, induces lymphocytosis in bovine leukemia virus-infected sheep. Proc Natl Acad Sci U S A. 2002; 99(15):10048-53. PMC: 126622. DOI: 10.1073/pnas.142100999. View

Debacq C, Asquith B, Reichert M, Burny A, Kettmann R, Willems L . Reduced cell turnover in bovine leukemia virus-infected, persistently lymphocytotic cattle. J Virol. 2003; 77(24):13073-83. PMC: 296050. DOI: 10.1128/jvi.77.24.13073-13083.2003. View

Twizere J, Kruys V, Lefebvre L, Vanderplasschen A, Collete D, Debacq C . Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. J Natl Cancer Inst. 2003; 95(24):1846-59. DOI: 10.1093/jnci/djg118. View

Derse D . Bovine leukemia virus transcription is controlled by a virus-encoded trans-acting factor and by cis-acting response elements. J Virol. 1987; 61(8):2462-71. PMC: 255671. DOI: 10.1128/JVI.61.8.2462-2471.1987. View

Derse D . trans-acting regulation of bovine leukemia virus mRNA processing. J Virol. 1988; 62(4):1115-9. PMC: 253117. DOI: 10.1128/JVI.62.4.1115-1119.1988. View

10.

Willems L, Kettmann R, Chen G, Portetelle D, Burny A, Derse D . A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat. J Virol. 1992; 66(2):766-72. PMC: 240776. DOI: 10.1128/JVI.66.2.766-772.1992. View

11.

Willems L, Grimonpont C, Heremans H, REBEYROTTE N, Chen G, Portetelle D . Mutations in the bovine leukemia virus Tax protein can abrogate the long terminal repeat-directed transactivating activity without concomitant loss of transforming potential. Proc Natl Acad Sci U S A. 1992; 89(9):3957-61. PMC: 525610. DOI: 10.1073/pnas.89.9.3957. View

12.

Willems L, Thienpont E, Kerkhofs P, Burny A, MAMMERICKX M, Kettmann R . Bovine leukemia virus, an animal model for the study of intrastrain variability. J Virol. 1993; 67(2):1086-9. PMC: 237465. DOI: 10.1128/JVI.67.2.1086-1089.1993. View

13.

Mansky L, Temin H . Lower mutation rate of bovine leukemia virus relative to that of spleen necrosis virus. J Virol. 1994; 68(1):494-9. PMC: 236310. DOI: 10.1128/JVI.68.1.494-499.1994. View

14.

Willems L, Kerkhofs P, Dequiedt F, Portetelle D, MAMMERICKX M, Burny A . Attenuation of bovine leukemia virus by deletion of R3 and G4 open reading frames. Proc Natl Acad Sci U S A. 1994; 91(24):11532-6. PMC: 45265. DOI: 10.1073/pnas.91.24.11532. View

15.

Willems L, Gatot J, MAMMERICKX M, Portetelle D, Burny A, Kerkhofs P . The YXXL signalling motifs of the bovine leukemia virus transmembrane protein are required for in vivo infection and maintenance of high viral loads. J Virol. 1995; 69(7):4137-41. PMC: 189149. DOI: 10.1128/JVI.69.7.4137-4141.1995. View

16.

Adam E, Kerkhofs P, MAMMERICKX M, Burny A, Kettmann R, Willems L . The CREB, ATF-1, and ATF-2 transcription factors from bovine leukemia virus-infected B lymphocytes activate viral expression. J Virol. 1996; 70(3):1990-9. PMC: 190028. DOI: 10.1128/JVI.70.3.1990-1999.1996. View

17.

Kerkhofs P, Heremans H, Burny A, Kettmann R, Willems L . In vitro and in vivo oncogenic potential of bovine leukemia virus G4 protein. J Virol. 1998; 72(3):2554-9. PMC: 109563. DOI: 10.1128/JVI.72.3.2554-2559.1998. View

18.

Gatot J, Callebaut I, Mornon J, Portetelle D, Burny A, Kerkhofs P . Conservative mutations in the immunosuppressive region of the bovine leukemia virus transmembrane protein affect fusion but not infectivity in vivo. J Biol Chem. 1998; 273(21):12870-80. DOI: 10.1074/jbc.273.21.12870. View

19.

Debacq C, Alcaraz M, Mortreux F, Kerkhofs P, Kettmann R, Willems L . Reduced proviral loads during primo-infection of sheep by Bovine Leukemia virus attenuated mutants. Retrovirology. 2004; 1:31. PMC: 526217. DOI: 10.1186/1742-4690-1-31. View

20.

Achachi A, Florins A, Gillet N, Debacq C, Urbain P, Foutsop G . Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo. Proc Natl Acad Sci U S A. 2005; 102(29):10309-14. PMC: 1177395. DOI: 10.1073/pnas.0504248102. View