Antecedents of Inflammation Biomarkers in Preterm Newborns on Days 21 and 28

Overview

Journal Acta Paediatr

Specialty Pediatrics

Date 2015 Nov 27

PMID 26610180

Citations 9

Authors

Alan Leviton

Elizabeth N Allred

Raina N Fichorova

Karl C K Kuban

T Michael OShea

Olaf Dammann

Affiliations

Soon will be listed here.

Abstract

Aim: Most studies of systemic inflammation in very preterm newborns focus on assessments made during the first two weeks. The purpose of this study was to identify some of the antecedents of systemic inflammation evident during postnatal weeks three and four.

Methods: We measured the protein concentrations in blood spots collected on postnatal days 21 (N = 176) and 28 (N = 157) from infants born before the 28th week of gestation and sought correlates of measurements in the top quartile. Odds ratios of elevated concentrations were calculated for the most obvious correlates.

Results: Infants born for maternal and foetal indications were more likely than their peers to have top quartile concentrations of IL-beta, IL-8, TNF-alpha and ICAM-1 on both days 21 and 28. Similarly, infants whose birthweight Z-score was <-2 or between -1 and -2 were also more likely than their peers to have elevated concentrations of these proteins.

Conclusion: Markers of systemic inflammation in the very preterm newborn during the third and fourth postnatal weeks are most strongly associated with maternal and foetal indications for (very preterm) delivery and their common correlate/consequence, foetal growth restriction.

Citing Articles

CpG methylation patterns in placenta and neonatal blood are differentially associated with neonatal inflammation.

Eaves L, Enggasser A, Camerota M, Gogcu S, Gower W, Hartwell H Pediatr Res. 2022; 93(4):1072-1084.

PMID: 35764815 PMC: 10289042. DOI: 10.1038/s41390-022-02150-4.

In-line filtration in very preterm neonates: a randomized controlled trial.

Virlouvet A, Pansiot J, Toumazi A, Colella M, Capewell A, Guerriero E Sci Rep. 2020; 10(1):5003.

PMID: 32193413 PMC: 7081338. DOI: 10.1038/s41598-020-61815-4.

Beyond Anesthesia Toxicity: Anesthetic Considerations to Lessen the Risk of Neonatal Neurological Injury.

McCann M, Lee J, Inder T Anesth Analg. 2019; 129(5):1354-1364.

PMID: 31517675 PMC: 7032045. DOI: 10.1213/ANE.0000000000004271.

Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury.

Fleiss B, Wong F, Brownfoot F, Shearer I, Baud O, Walker D Front Endocrinol (Lausanne). 2019; 10:188.

PMID: 30984110 PMC: 6449431. DOI: 10.3389/fendo.2019.00188.

Socioeconomic status and early blood concentrations of inflammation-related and neurotrophic proteins among extremely preterm newborns.

Leviton A, Allred E, Dammann O, Joseph R, Fichorova R, OShea T PLoS One. 2019; 14(3):e0214154.

PMID: 30913246 PMC: 6435168. DOI: 10.1371/journal.pone.0214154.

References

Bose C, Laughon M, Allred E, Van Marter L, OShea T, Ehrenkranz R . Blood protein concentrations in the first two postnatal weeks that predict bronchopulmonary dysplasia among infants born before the 28th week of gestation. Pediatr Res. 2010; 69(4):347-53. PMC: 3083822. DOI: 10.1203/PDR.0b013e31820a58f3. View

Remacle C, Bieswal F, Reusens B . Programming of obesity and cardiovascular disease. Int J Obes Relat Metab Disord. 2004; 28 Suppl 3:S46-53. DOI: 10.1038/sj.ijo.0802800. View

Heerwagen M, Miller M, Barbour L, Friedman J . Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol. 2010; 299(3):R711-22. PMC: 2944425. DOI: 10.1152/ajpregu.00310.2010. View

Leviton A, Allred E, Kuban K, Dammann O, Fichorova R, OShea T . Blood protein concentrations in the first two postnatal weeks associated with early postnatal blood gas derangements among infants born before the 28th week of gestation. The ELGAN Study. Cytokine. 2011; 56(2):392-8. PMC: 4747654. DOI: 10.1016/j.cyto.2011.07.014. View

McElrath T, Allred E, Van Marter L, Fichorova R, Leviton A . Perinatal systemic inflammatory responses of growth-restricted preterm newborns. Acta Paediatr. 2013; 102(10):e439-42. PMC: 3773878. DOI: 10.1111/apa.12339. View

Davis E, Newton L, Lewandowski A, Lazdam M, Kelly B, Kyriakou T . Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies. Clin Sci (Lond). 2012; 123(2):53-72. PMC: 3315178. DOI: 10.1042/CS20110627. View

Herrera-Garcia G, Contag S . Maternal preeclampsia and risk for cardiovascular disease in offspring. Curr Hypertens Rep. 2014; 16(9):475. DOI: 10.1007/s11906-014-0475-3. View

Fichorova R, Beatty N, Sassi R, Yamamoto H, Allred E, Leviton A . Systemic inflammation in the extremely low gestational age newborn following maternal genitourinary infections. Am J Reprod Immunol. 2014; 73(2):162-74. PMC: 4293273. DOI: 10.1111/aji.12313. View

Zak D, Aderem A . Systems biology of innate immunity. Immunol Rev. 2009; 227(1):264-82. PMC: 2697920. DOI: 10.1111/j.1600-065X.2008.00721.x. View

10.

Boeldt D, Hankes A, Alvarez R, Khurshid N, Balistreri M, Grummer M . Pregnancy programming and preeclampsia: identifying a human endothelial model to study pregnancy-adapted endothelial function and endothelial adaptive failure in preeclamptic subjects. Adv Exp Med Biol. 2014; 814:27-47. DOI: 10.1007/978-1-4939-1031-1_4. View

11.

Fernandez E, Perez R, Hernandez A, Tejada P, Arteta M, Ramos J . Factors and Mechanisms for Pharmacokinetic Differences between Pediatric Population and Adults. Pharmaceutics. 2013; 3(1):53-72. PMC: 3857037. DOI: 10.3390/pharmaceutics3010053. View

12.

Bose C, Van Marter L, Laughon M, OShea T, Allred E, Karna P . Fetal growth restriction and chronic lung disease among infants born before the 28th week of gestation. Pediatrics. 2009; 124(3):e450-8. PMC: 2891899. DOI: 10.1542/peds.2008-3249. View

13.

Escudero C, Roberts J, Myatt L, Feoktistov I . Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming. Front Pharmacol. 2014; 5:134. PMC: 4046493. DOI: 10.3389/fphar.2014.00134. View

14.

Ginsberg G, Hattis D, Sonawane B, Russ A, Banati P, Kozlak M . Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature. Toxicol Sci. 2002; 66(2):185-200. DOI: 10.1093/toxsci/66.2.185. View

15.

Fichorova R, Onderdonk A, Yamamoto H, Delaney M, DuBois A, Allred E . Maternal microbe-specific modulation of inflammatory response in extremely low-gestational-age newborns. mBio. 2011; 2(1):e00280-10. PMC: 3025357. DOI: 10.1128/mBio.00280-10. View

16.

Streimish I, Ehrenkranz R, Allred E, OShea T, Kuban K, Paneth N . Birth weight- and fetal weight-growth restriction: impact on neurodevelopment. Early Hum Dev. 2012; 88(9):765-71. PMC: 3694609. DOI: 10.1016/j.earlhumdev.2012.04.004. View

17.

Saghir S, Khan S, McCoy A . Ontogeny of mammalian metabolizing enzymes in humans and animals used in toxicological studies. Crit Rev Toxicol. 2012; 42(5):323-57. DOI: 10.3109/10408444.2012.674100. View

18.

Bose C, Laughon M, Allred E, OShea T, Van Marter L, Ehrenkranz R . Systemic inflammation associated with mechanical ventilation among extremely preterm infants. Cytokine. 2012; 61(1):315-22. PMC: 3518391. DOI: 10.1016/j.cyto.2012.10.014. View

19.

Leviton A, OShea T, Bednarek F, Allred E, Fichorova R, Dammann O . Systemic responses of preterm newborns with presumed or documented bacteraemia. Acta Paediatr. 2011; 101(4):355-9. PMC: 3294175. DOI: 10.1111/j.1651-2227.2011.02527.x. View

20.

McElrath T, Fichorova R, Allred E, Hecht J, Ismail M, Yuan H . Blood protein profiles of infants born before 28 weeks differ by pregnancy complication. Am J Obstet Gynecol. 2011; 204(5):418.e1-418.e12. DOI: 10.1016/j.ajog.2010.12.010. View