Clinical Significance of IL-2 and IL-10 Gene Polymorphisms and Serum Levels in Patients with Basal-cell Carcinoma

Overview

Journal Biomark Med

Specialties Biochemistry
General Medicine

Date 2015 Nov 27

PMID 26609634

Citations 8

Authors

Michal Sobjanek

Monika Zablotna

Ewa Bien

Jolanta Glen

Malgorzata Sokolowska-Wojdylo

Katarzyna Ruckemann-Dziurdzinska

Roman Nowicki

Affiliations

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Abstract

Materials & Methods: Polymorphic variants of IL-2 gene (-330 T/G and +166 G/T), IL-10 gene (-1082 G/A and -819 C/T) and serum cytokines concentrations in the group of 179 patients with BCC and 173 controls were analyzed.

Results: The presence of the IL-2 -330 GG genotype or IL-10 -1082 GA increased the risk of BCC (OR 3.68) (OR 3.07). IL-10 -1082 AA or GA and IL-2 -330 GG genotype increased the risk of BCC (OR 9.63). IL-2 serum levels were significantly lower (p < 0.0004) in BCC patients while IL-10 concentration was significantly higher (p < 0.00001).

Conclusion: The polymorphisms in IL-2 and IL-10 genes may contribute to BCC susceptibility and influence the clinical course of BCC in polish population.

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