The IMSI Procedure Improves Laboratory and Clinical Outcomes Without Compromising the Aneuploidy Rate When Compared to the Classical ICSI Procedure

Overview

Journal Clin Med Insights Reprod Health

Publisher Sage Publications

Specialty Reproductive Medicine

Date 2015 Nov 27

PMID 26609251

Citations 9

Authors

Daniel Luna

Roly Hilario

Julio Duenas-Chacon

Rocio Romero

Patricia Zavala

Lucy Villegas

Javier Garcia-Ferreyra

Affiliations

Soon will be listed here.

Abstract

Purpose: The intracytoplasmic morphologically selected sperm injection (IMSI) procedure has been associated with better laboratory and clinical outcomes in assisted reproduction technologies. Less information is available regarding the relationship between embryo aneuploidy rate and the IMSI procedure. The aim of this study is to compare the clinical outcomes and chromosomal status of IMSI-derived embryos with those obtained from intracytoplasmic sperm injection (ICSI) in order to establish a clearer view of the benefits of IMSI in infertile patients.

Methods: We retrospectively analyzed a total of 11 cycles of IMSI and 20 cycles of ICSI with preimplantation genetic diagnosis. The fertilization rate, cleavage rate, embryo quality, blastocyst development, aneuploidy rate, pregnancy rate, implantation rate, and miscarriage rate were compared between the groups.

Results: Similar rates of fertilization (70% and 73%), cleavage (98% and 100%), and aneuploidy (76.9% and 70.9%) were observed in the IMSI and ICSI groups, respectively. The IMSI group had significantly more good quality embryos at day 3 (95% vs 73%), higher blastocyst development rates (33% vs 19%), and greater number of hatching blastocysts (43% vs 28%), cycles with at least one blastocyst at day 5 (55% vs 35%), and blastocysts with good trophoectoderm morphology (21% vs 6%) compared with the ICSI group (P < 0.001). Significantly higher implantation rates were observed in the IMSI group compared with the ICSI group (57% vs 27%; P < 0.05). Pregnancy and miscarriage rates were similar in both groups (80% vs 50% and 0% vs 33%, respectively).

Conclusion: The IMSI procedure significantly improves the embryo quality/development by increasing the implantation rates without affecting the chromosomal status of embryos. There is a tendency for the IMSI procedure to enhance the pregnancy rates and lower the miscarriage rates when compared with ICSI.

Citing Articles

IMSI-Guidelines for Sperm Quality Assessment.

Lukaszuk K, Jakiel G, Woclawek Potocka I, Kiewisz J, Olszewska J, Sieg W Diagnostics (Basel). 2022; 12(1).

PMID: 35054359 PMC: 8774575. DOI: 10.3390/diagnostics12010192.

Sperm selection during ICSI treatments reduces single- but not double-strand DNA break values compared to the semen sample.

Lara-Cerrillo S, Ribas-Maynou J, Rosado-Iglesias C, Lacruz-Ruiz T, Benet J, Garcia-Peiro A J Assist Reprod Genet. 2021; 38(5):1187-1196.

PMID: 33660206 PMC: 8190426. DOI: 10.1007/s10815-021-02129-w.

The Beneficial Role of Intra Cytoplasmic Morphologically Selected Sperm Injection (IMSI) in Assisted Reproduction.

Mangoli E, Khalili M J Reprod Infertil. 2020; 21(1):3-10.

PMID: 32175260 PMC: 7048693.

Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies.

Navarrete F, Aguila L, Martin-Hidalgo D, Tourzani D, Luque G, Ardestani G Front Cell Dev Biol. 2019; 7:262.

PMID: 31750304 PMC: 6848031. DOI: 10.3389/fcell.2019.00262.

Deep learning-based selection of human sperm with high DNA integrity.

McCallum C, Riordon J, Wang Y, Kong T, You J, Sanner S Commun Biol. 2019; 2:250.

PMID: 31286067 PMC: 6610103. DOI: 10.1038/s42003-019-0491-6.

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