Primary Large-Cell Neuroendocrine Carcinoma of the Breast Occurring in a Pre-Menopausal Woman

Overview

Journal Breast Care (Basel)

Publisher Karger

Date 2015 Nov 25

PMID 26600766

Citations 5

Authors

Noriko Yoshimura

Tatsunari Sasada

Shuji Yonehara

Affiliations

Soon will be listed here.

Abstract

Background: Primary large-cell neuroendocrine carcinoma of the breast (LCNEC-breast) in pre-menopausal women is extremely rare.

Case Report: A 34-year-old woman presented with a mass in the left breast that was diagnosed as neuroendocrine carcinoma by needle biopsy. Computed tomography revealed no lymph node swelling or distant organ metastasis. Left mastectomy and sentinel lymph node biopsy were performed and metastasis to the axial lymph node was detected. Left axillary lymph node dissection was performed and histopathological and immunohistochemical examination revealed that the tumor was an LCNEC-breast, which was 6.0 cm in size and positive for the neuroendocrine markers (neuron-specific enolase, chromogranin A, and synaptophysin). The tumor cells were hormone-receptor positive and HER2 negative. The patient refused any adjuvant hormonal therapy, chemotherapy or radiotherapy. She has been followed up for 4 years without medication, and no recurrence has been noted.

Conclusion: We present a case of LCNEC-breast in a 34-year-old woman. Our case represents the youngest woman with LCNEC-breast reported in the English literature.

Citing Articles

A high-quality model for predicting the prognosis of breast neuroendocrine carcinoma to help clinicians decide on appropriate treatment methods: A population-based analysis.

Chen Y, Xu X, Xu J, Di T, Wang X, Huo L Transl Oncol. 2022; 22:101467.

PMID: 35700595 PMC: 9198476. DOI: 10.1016/j.tranon.2022.101467.

Primary Neuroendocrine Neoplasms of the Breast: Still Open Issues.

Gallo M, Campione S, Di Vito V, Fortunati N, Lo Calzo F, Messina E Front Endocrinol (Lausanne). 2021; 11:610230.

PMID: 33584543 PMC: 7874233. DOI: 10.3389/fendo.2020.610230.

Primary neuroendocrine carcinoma of the breast: a rare presentation and review of the literature.

Salemis N Intractable Rare Dis Res. 2020; 9(4):233-246.

PMID: 33139983 PMC: 7586876. DOI: 10.5582/irdr.2020.03046.

Neuroendocrine breast carcinoma: a rare but challenging entity.

Trevisi E, La Salvia A, Daniele L, Brizzi M, De Rosa G, Scagliotti G Med Oncol. 2020; 37(8):70.

PMID: 32712767 PMC: 7382662. DOI: 10.1007/s12032-020-01396-4.

[Primary large cell neuroendocrine carcinoma of the breast: a rare tumor in humans].

Safini F, Bouchbika Z, Bennani Z, Belkheiri S, El Attar H, Benchakroun N Pan Afr Med J. 2017; 25:205.

PMID: 28292162 PMC: 5326194. DOI: 10.11604/pamj.2016.25.205.10366.

References

Tsai W, Yu J, Lin C, Hsieh C . Primary alveolar-type large cell neuroendocrine carcinoma of the breast. Breast J. 2005; 11(6):487. DOI: 10.1111/j.1075-122X.2005.00158.x. View

Okoshi K, Saiga T, Hisamori S, Iwaisako K, Kobayashi H, Ogawa H . A case of cytokeratin 20-positive large-cell neuroendocrine carcinoma of the breast. Breast Cancer. 2009; 19(4):360-4. DOI: 10.1007/s12282-009-0160-6. View

Bocker W . [WHO classification of breast tumors and tumors of the female genital organs: pathology and genetics]. Verh Dtsch Ges Pathol. 2003; 86:116-9. View

Kim J, Woo O, Cho K, Seo B, Yong H, Kim A . Primary large cell neuroendocrine carcinoma of the breast: radiologic and pathologic findings. J Korean Med Sci. 2009; 23(6):1118-20. PMC: 2610652. DOI: 10.3346/jkms.2008.23.6.1118. View

Lahat G, Lev D, Gerstenhaber F, Madewell J, Le-Petross H, Pollock R . Sarcomas of the breast. Expert Rev Anticancer Ther. 2012; 12(8):1045-51. DOI: 10.1586/era.12.82. View

Viacava P, Naccarato A, Nardini V, Bevilacqua G . Breast carcinoma with osteoclast-like giant cells: immunohistochemical and ultrastructural study of a case and review of the literature. Tumori. 1995; 81(2):135-41. DOI: 10.1177/030089169508100213. View

Berruti A, Saini A, Leonardo E, Cappia S, Borasio P, Dogliotti L . Management of neuroendocrine differentiated breast carcinoma. Breast. 2004; 13(6):527-9. DOI: 10.1016/j.breast.2004.06.007. View

Papotti M, Macri L, Finzi G, Capella C, Eusebi V, Bussolati G . Neuroendocrine differentiation in carcinomas of the breast: a study of 51 cases. Semin Diagn Pathol. 1989; 6(2):174-88. View

Upalakalin J, Collins L, Tawa N, Parangi S . Carcinoid tumors in the breast. Am J Surg. 2006; 191(6):799-805. DOI: 10.1016/j.amjsurg.2005.10.021. View

10.

Oberg K, Casanovas O, Castano J, Chung D, Delle Fave G, Denefle P . Molecular pathogenesis of neuroendocrine tumors: implications for current and future therapeutic approaches. Clin Cancer Res. 2013; 19(11):2842-9. DOI: 10.1158/1078-0432.CCR-12-3458. View

11.

Sapino A, Righi L, Cassoni P, Papotti M, Pietribiasi F, Bussolati G . Expression of the neuroendocrine phenotype in carcinomas of the breast. Semin Diagn Pathol. 2000; 17(2):127-37. View

12.

Avenia N, Sanguinetti A, Cirocchi R, Bistoni G, Trastulli S, DAjello F . Primary breast lymphomas: a multicentric experience. World J Surg Oncol. 2010; 8:53. PMC: 2903594. DOI: 10.1186/1477-7819-8-53. View

13.

Dina R, Eusebi V . Clear cell tumors of the breast. Semin Diagn Pathol. 1997; 14(3):175-82. View

14.

Le Treut J, Sault M, Lena H, Souquet P, Vergnenegre A, Le Caer H . Multicentre phase II study of cisplatin-etoposide chemotherapy for advanced large-cell neuroendocrine lung carcinoma: the GFPC 0302 study. Ann Oncol. 2013; 24(6):1548-52. DOI: 10.1093/annonc/mdt009. View

15.

Maluf H, Koerner F . Carcinomas of the breast with endocrine differentiation: a review. Virchows Arch. 1994; 425(5):449-57. DOI: 10.1007/BF00197547. View

16.

Alkaied H, Harris K, Azab B, Dai Q . Primary neuroendocrine breast cancer, how much do we know so far?. Med Oncol. 2012; 29(4):2613-8. DOI: 10.1007/s12032-012-0222-z. View

17.

Yerushalmi R, Hayes M, Gelmon K . Breast carcinoma--rare types: review of the literature. Ann Oncol. 2009; 20(11):1763-70. DOI: 10.1093/annonc/mdp245. View

18.

Niho S, Kenmotsu H, Sekine I, Ishii G, Ishikawa Y, Noguchi M . Combination chemotherapy with irinotecan and cisplatin for large-cell neuroendocrine carcinoma of the lung: a multicenter phase II study. J Thorac Oncol. 2013; 8(7):980-4. DOI: 10.1097/JTO.0b013e31828f6989. View

19.

Iyoda A, Hiroshima K, Nakatani Y, Fujisawa T . Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. Ann Thorac Surg. 2007; 84(2):702-7. DOI: 10.1016/j.athoracsur.2007.03.093. View

20.

Yazbek Hanna M, Leung E, Rogers C, Pilgrim S . Primary large-cell neuroendocrine tumor of the breast. Breast J. 2013; 19(2):204-6. DOI: 10.1111/tbj.12081. View