Dietary Phytochemical Index and the Risk of Insulin Resistance and β-cell Dysfunction: a Prospective Approach in Tehran Lipid and Glucose Study

Overview

Journal Int J Food Sci Nutr

Publisher Informa Healthcare

Specialty Nutritional Sciences

Date 2015 Nov 25

PMID 26600067

Citations 28

Authors

Zahra Bahadoran

Parvin Mirmiran

Maryam Tohidi

Fereidoun Azizi

Affiliations

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Abstract

Background: In this study, we aimed to investigate the association of dietary phytochemical index (DPI) with insulin resistance, β-cell dysfunction, and insulin sensitivity.

Methods: This longitudinal study was conducted on 1141 participants of the Tehran Lipid and Glucose Study. Dietary data were collected using a validated semi-quantitative FFQ with 168 food items at baseline and DPI was calculated. Fasting serum insulin and glucose were measured at baseline and again after a 3-year of follow-up.

Results: After 3-years of follow-up, the risk of hyperinsulinemia significantly decreased by 65 (OR = 0.35, 95% CI = 0.21-0.60) and 86% (OR = 0.14, 0.07-0.29), in the third and fourth quartile categories of DPI, respectively. The occurrence of insulin resistance and insulin insensitivity in participants with higher DPI was significantly lower than the others (OR = 0.48, 95% CI = 0.25-0.93 and OR = 0.11, 95% CI = 0.05-0.24, respectively).

Conclusion: Higher consumption of phytochemical-rich foods may have protective effects against development of insulin resistance.

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Jalalzadeh M, Nasli-Esfahani E, Montazer M, Geravand F, Hajian P, Heidari-Seyedmahalle M BMC Endocr Disord. 2024; 24(1):226.

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