Higher Serum Dehydroepiandrosterone Sulfate Protects Against the Onset of Depression in the Elderly: Findings from the English Longitudinal Study of Aging (ELSA)

Overview

Journal Psychoneuroendocrinology

Specialties Endocrinology
Neurology
Psychiatry

Date 2015 Nov 25

PMID 26600009

Citations 15

Authors

Luis H Souza-Teodoro

Cesar de Oliveira

Kate Walters

Livia A Carvalho

Affiliations

Soon will be listed here.

Abstract

Depression is one of the major causes of disability worldwide, but the complete etiology of depression is not fully understood. Dehydroepiandrosterone (DHEA) and its sulphated form DHEA(S) have been associated with mood and healthy aging. Associations with mental illness over the middle to late years of life have not yet been extensively investigated in large, western community-dwelling samples. The aim of this study was to investigate whether low DHEA(S) levels are associated with the development of depressive symptoms in a large longitudinal cohort study of older men and women. We assessed data from English Longitudinal Study of Aging (ELSA) to evaluate the association of DHEA(S) levels and depressive symptoms measured by Center for Epidemiologic Studies Scale (CES-D) at baseline (n=3083) and at 4-year follow-up (n=3009). At baseline, there was an inverse association between DHEA(S) and depressive symptoms (B=-0.252, p=0.014). Adjustments for physical illnesses, impairments in cognitive function and health behaviors abolished this association (p=0.109) at baseline. Decreased DHEA(S) levels at baseline also predicted incident depression at 4-year follow-up (B=-0.332, p<0.001). In conclusion, higher DHEA(S) levels were associated with reduced risk of developing depressive symptoms in both men and women.

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References

Yaffe K, Ettinger B, Pressman A, Seeley D, Whooley M, Schaefer C . Neuropsychiatric function and dehydroepiandrosterone sulfate in elderly women: a prospective study. Biol Psychiatry. 1998; 43(9):694-700. DOI: 10.1016/s0006-3223(97)00303-x. View

Glei D, Goldman N, Weinstein M, Liu I . Dehydroepiandrosterone sulfate (DHEAS) and health: does the relationship differ by sex?. Exp Gerontol. 2004; 39(3):321-31. DOI: 10.1016/j.exger.2003.11.003. View

TSjoen G, De Vos S, Goemaere S, van Pottelbergh I, Dierick M, Van Heeringen C . Sex steroid level, androgen receptor polymorphism, and depressive symptoms in healthy elderly men. J Am Geriatr Soc. 2005; 53(4):636-42. DOI: 10.1111/j.1532-5415.2005.53212.x. View

Turvey C, Wallace R, Herzog R . A revised CES-D measure of depressive symptoms and a DSM-based measure of major depressive episodes in the elderly. Int Psychogeriatr. 2001; 11(2):139-48. DOI: 10.1017/s1041610299005694. View

Zarrouf F, Artz S, Griffith J, Sirbu C, Kommor M . Testosterone and depression: systematic review and meta-analysis. J Psychiatr Pract. 2009; 15(4):289-305. DOI: 10.1097/01.pra.0000358315.88931.fc. View

Heaney J, Carroll D, Phillips A . DHEA, DHEA-S and cortisol responses to acute exercise in older adults in relation to exercise training status and sex. Age (Dordr). 2011; 35(2):395-405. PMC: 3592957. DOI: 10.1007/s11357-011-9345-y. View

Binello E, Gordon C . Clinical uses and misuses of dehydroepiandrosterone. Curr Opin Pharmacol. 2003; 3(6):635-41. DOI: 10.1016/j.coph.2003.07.006. View

Hamer M, Molloy G, de Oliveira C, Demakakos P . Leisure time physical activity, risk of depressive symptoms, and inflammatory mediators: the English Longitudinal Study of Ageing. Psychoneuroendocrinology. 2009; 34(7):1050-5. DOI: 10.1016/j.psyneuen.2009.02.004. View

Mazat L, Lafont S, Berr C, Debuire B, Tessier J, Dartigues J . Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc Natl Acad Sci U S A. 2001; 98(14):8145-50. PMC: 35482. DOI: 10.1073/pnas.121177998. View

10.

Haren M, Malmstrom T, Banks W, Patrick P, Miller D, Morley J . Lower serum DHEAS levels are associated with a higher degree of physical disability and depressive symptoms in middle-aged to older African American women. Maturitas. 2007; 57(4):347-60. PMC: 2041800. DOI: 10.1016/j.maturitas.2007.03.003. View

11.

Barrett-Connor E, von Muhlen D, Laughlin G, Kripke A . Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: the Rancho Bernardo Study. J Am Geriatr Soc. 1999; 47(6):685-91. DOI: 10.1111/j.1532-5415.1999.tb01590.x. View

12.

Samaras N, Samaras D, Frangos E, Forster A, Philippe J . A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: is treatment beneficial?. Rejuvenation Res. 2013; 16(4):285-94. PMC: 3746247. DOI: 10.1089/rej.2013.1425. View

13.

Kizildere S, Gluck T, Zietz B, Scholmerich J, Straub R . During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH. Eur J Endocrinol. 2003; 148(1):45-53. DOI: 10.1530/eje.0.1480045. View

14.

Buford T, Willoughby D . Impact of DHEA(S) and cortisol on immune function in aging: a brief review. Appl Physiol Nutr Metab. 2008; 33(3):429-33. DOI: 10.1139/H08-013. View

15.

Maurice T, Roman F, Privat A . Modulation by neurosteroids of the in vivo (+)-[3H]SKF-10,047 binding to sigma 1 receptors in the mouse forebrain. J Neurosci Res. 1996; 46(6):734-43. DOI: 10.1002/(SICI)1097-4547(19961215)46:6<734::AID-JNR10>3.0.CO;2-U. View

16.

Phillips A, Batty G, Gale C, Lord J, Arlt W, Carroll D . Major depressive disorder, generalised anxiety disorder, and their comorbidity: associations with cortisol in the Vietnam Experience Study. Psychoneuroendocrinology. 2010; 36(5):682-90. DOI: 10.1016/j.psyneuen.2010.09.011. View

17.

Luppa M, Sikorski C, Luck T, Ehreke L, Konnopka A, Wiese B . Age- and gender-specific prevalence of depression in latest-life--systematic review and meta-analysis. J Affect Disord. 2011; 136(3):212-21. DOI: 10.1016/j.jad.2010.11.033. View

18.

Bauer M . Chronic stress and immunosenescence: a review. Neuroimmunomodulation. 2008; 15(4-6):241-50. DOI: 10.1159/000156467. View

19.

Maninger N, Wolkowitz O, Reus V, Epel E, Mellon S . Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front Neuroendocrinol. 2008; 30(1):65-91. PMC: 2725024. DOI: 10.1016/j.yfrne.2008.11.002. View

20.

McEwen B, Biron C, Brunson K, Bulloch K, CHAMBERS W, Dhabhar F . The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions. Brain Res Brain Res Rev. 1997; 23(1-2):79-133. DOI: 10.1016/s0165-0173(96)00012-4. View