Association of Susceptible Genotypes to Periodontal Disease with the Clinical Outcome and Tooth Survival After Non-surgical Periodontal Therapy: A Systematic Review and Meta-analysis

Overview

Journal Med Oral Patol Oral Cir Bucal

Specialty Dentistry

Date 2015 Nov 24

PMID 26595831

Citations 3

Authors

Georgios-Sokratis Chatzopoulos

Aikaterini-Ellisavet Doufexi

Fotini Kalogirou

Affiliations

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Abstract

Background: The real clinical utility of genetic testing is the prognostic value of genetic factors in the clinical outcome of periodontal treatment and the tooth survival. A meta-analysis was undertaken to estimate the effect of a susceptible genotype to periodontitis on the clinical outcomes of non-surgical periodontal therapy and the tooth survival.

Material And Methods: A systematic search of MEDLINE-Pubmed, Cochrane Library and Scopus was performed. Additionally, a hand search was done in three journals. No specific language restriction was applied. Two reviewers screened independently titles and abstracts or full text copies. Quality assessment of all the included studies was held.

Results: Initial screening of electronic databases resulted in 283 articles. Ten studies met the inclusion criteria, nine of them examined the clinical outcome, while the other one investigated the tooth survival in susceptible individuals after non-surgical periodontal therapy. Eight of included studies were selected for the meta-analysis. IL-1 positive genotypes increase the risk of tooth loss, while no association found between the bleeding on probing (BOP), clinical attachment loss (CAL) and plaque index (PI) with the genotype status. Probing pocket depth (PPD) reduction in the first three months and in long-term results found to have a significant association with the genotype.

Conclusions: There is no difference in the clinical measurements after non-surgical periodontal treatment, apart from PPD. More publications are needed to identify a cause-effect relationship.

Citing Articles

Interleukin-6 and Interleukin-10 Gene Polymorphisms in Patients with Chronic Periodontitis and Response to Treatment after 3 Years.

Chatzopoulos G, Doufexi A, Zarenti S, Anastasopoulos M, Kouvatsi A Acta Stomatol Croat. 2020; 54(3):238-249.

PMID: 33132387 PMC: 7586901. DOI: 10.15644/asc54/3/2.

Clinical response to non-surgical periodontal treatment in patients with interleukin-6 and interleukin-10 polymorphisms.

Chatzopoulos G, Doufexi A, Kouvatsi A Med Oral Patol Oral Cir Bucal. 2017; 22(4):e446-e457.

PMID: 28624837 PMC: 5549518. DOI: 10.4317/medoral.21795.

Association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regenerative therapy: A systematic review.

Chatzopoulos G, Koidou V Med Oral Patol Oral Cir Bucal. 2016; 21(4):e456-64.

PMID: 26946210 PMC: 4920459. DOI: 10.4317/medoral.21105.

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