Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Overview

Journal Curr Mol Biol Rep

Specialty Biochemistry

Date 2015 Nov 24

PMID 26594613

Citations 3

Authors

Linda C Alskar

Christel A S Bergstrom

Affiliations

Soon will be listed here.

Abstract

In this review, we describe the in vitro tools currently used to identify when a lipid-based formulation has the potential to deliver a poorly water-soluble drug via the oral route. We describe the extent to which these tools reflect the in vivo performance of the formulation and, more importantly, we present strategies that we foresee will improve the in vitro-in vivo correlations. We also present emerging computational methods that are likely to allow large parts of the formulation development to be carried out in the computer rather than in the test tube. We suggest that these computational tools will also improve the mechanistic understanding of in vivo formulation performance in the complex and dynamic environment of the gut.

Citing Articles

Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development.

Nakmode D, Bhavana V, Thakor P, Madan J, Singh P, Singh S Pharmaceutics. 2022; 14(4).

PMID: 35456665 PMC: 9025782. DOI: 10.3390/pharmaceutics14040831.

Estimating the Oral Absorption from Self-Nanoemulsifying Drug Delivery Systems Using an In Vitro Lipolysis-Permeation Method.

Klitgaard M, Mullertz A, Berthelsen R Pharmaceutics. 2021; 13(4).

PMID: 33918449 PMC: 8065752. DOI: 10.3390/pharmaceutics13040489.

Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach.

Larsson P, Alskar L, Bergstrom C Mol Pharm. 2017; 14(12):4145-4153.

PMID: 28799773 PMC: 5836143. DOI: 10.1021/acs.molpharmaceut.7b00397.

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