Multiple Sources of Infection and Potential Endemic Characteristics of the Large Outbreak of Dengue in Guangdong in 2014

Overview

Journal Sci Rep

Specialty Science

Date 2015 Nov 24

PMID 26593240

Citations 15

Authors

Shu-Qun Shen

Hai-Xia Wei

Yong-Hang Fu

Hao Zhang

Qing-Yi Mo

Xiao-Jun Wang

Sheng-Qun Deng

Wei Zhao

Yu Liu

Xiao-Shuang Feng

Wei Chen

Hong-Juan Peng

Affiliations

Soon will be listed here.

Abstract

A large outbreak of dengue, with the most documented cases, occurred in Guangdong China in 2014. Epidemiological studies and phylogenetic analysis of the isolated dengue virus (DENV) showed this outbreak was attributed to multiple sources and caused by at least two genotypes of DENV-1 (Genotypes I and III) and two genotypes of DENV-2 (Cosmopolitan and Asian I Genotypes). A retrospective review and phylogenetic analysis of DENV isolated in Guangdong showed that DENV-1 Genotype I strains were reported continuously during 2004-2014, Genotype III strains were reported during 2009-2014 ; DENV-2 Cosmopolitan and Asian I Genotype strains were reported continuously during 2012-2014. At least 45,171 cases were reported in this outbreak, with 65.9% of the patients in the 21-55-year-old group. A trend toward a decrease in the daily newly emerged cases lagged by approximately 20 days compared with the mosquito density curve. Several epidemiological characteristics of this outbreak and the stably sustained serotypes and genotypes of DENV isolated in Guangdong suggest that Guangdong has been facing a threat of transforming from a dengue epidemic area to an endemic area. The high temperature, drenching rain, rapid urbanization, and pandemic of dengue in Southeast Asia may have contributed to this large outbreak of dengue.

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References

Wang B, Li Y, Feng Y, Zhou H, Liang Y, Dai J . Phylogenetic analysis of dengue virus reveals the high relatedness between imported and local strains during the 2013 dengue outbreak in Yunnan, China: a retrospective analysis. BMC Infect Dis. 2015; 15:142. PMC: 4377197. DOI: 10.1186/s12879-015-0908-x. View

Peng H, Lai H, Zhang Q, Xu B, Zhang H, Liu W . A local outbreak of dengue caused by an imported case in Dongguan China. BMC Public Health. 2012; 12:83. PMC: 3311058. DOI: 10.1186/1471-2458-12-83. View

Lanciotti R, Calisher C, Gubler D, Chang G, Vorndam A . Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol. 1992; 30(3):545-51. PMC: 265106. DOI: 10.1128/jcm.30.3.545-551.1992. View

Wilder-Smith A, Gubler D . Geographic expansion of dengue: the impact of international travel. Med Clin North Am. 2008; 92(6):1377-90, x. DOI: 10.1016/j.mcna.2008.07.002. View

Monath T . Dengue: the risk to developed and developing countries. Proc Natl Acad Sci U S A. 1994; 91(7):2395-400. PMC: 43378. DOI: 10.1073/pnas.91.7.2395. View

Wilder-Smith A, Schwartz E . Dengue in travelers. N Engl J Med. 2005; 353(9):924-32. DOI: 10.1056/NEJMra041927. View

Gubler D . Dengue/dengue haemorrhagic fever: history and current status. Novartis Found Symp. 2007; 277:3-16. DOI: 10.1002/0470058005.ch2. View

Jin L, Li D . A recent survey of mosquito fauna in Guangdong Province,southern China, with a review of past records [corrected]. Med Vet Entomol. 2009; 22(4):359-63. DOI: 10.1111/j.1365-2915.2008.00758.x. View

Normile D . Tropical medicine. Surprising new dengue virus throws a spanner in disease control efforts. Science. 2013; 342(6157):415. DOI: 10.1126/science.342.6157.415. View

10.

Fan J, Lin H, Wang C, Bai L, Yang S, Chu C . Identifying the high-risk areas and associated meteorological factors of dengue transmission in Guangdong Province, China from 2005 to 2011. Epidemiol Infect. 2013; 142(3):634-43. PMC: 9161228. DOI: 10.1017/S0950268813001519. View

11.

Bhatt S, Gething P, Brady O, Messina J, Farlow A, Moyes C . The global distribution and burden of dengue. Nature. 2013; 496(7446):504-7. PMC: 3651993. DOI: 10.1038/nature12060. View

12.

Li Y, Kamara F, Zhou G, Puthiyakunnon S, Li C, Liu Y . Urbanization increases Aedes albopictus larval habitats and accelerates mosquito development and survivorship. PLoS Negl Trop Dis. 2014; 8(11):e3301. PMC: 4230920. DOI: 10.1371/journal.pntd.0003301. View

13.

Lambrechts L, Scott T, Gubler D . Consequences of the expanding global distribution of Aedes albopictus for dengue virus transmission. PLoS Negl Trop Dis. 2010; 4(5):e646. PMC: 2876112. DOI: 10.1371/journal.pntd.0000646. View

14.

Chen B, Liu Q . Dengue fever in China. Lancet. 2015; 385(9978):1621-2. DOI: 10.1016/S0140-6736(15)60793-0. View

15.

Jiang C, Schieffelin J, Li J, Sun W . Dengue fever: a new challenge for China?. Glob Health Action. 2014; 7:26421. PMC: 4272412. DOI: 10.3402/gha.v7.26421. View

16.

Liu Q, Liu X, Cirendunzhu , Woodward A, Pengcuociren , Bai L . Mosquitoes established in Lhasa city, Tibet, China. Parasit Vectors. 2013; 6:224. PMC: 3750258. DOI: 10.1186/1756-3305-6-224. View

17.

Wu J, Lun Z, James A, Chen X . Dengue Fever in mainland China. Am J Trop Med Hyg. 2010; 83(3):664-71. PMC: 2929067. DOI: 10.4269/ajtmh.2010.09-0755. View

18.

Gubler D . Dengue, Urbanization and Globalization: The Unholy Trinity of the 21(st) Century. Trop Med Health. 2012; 39(4 Suppl):3-11. PMC: 3317603. DOI: 10.2149/tmh.2011-S05. View

19.

Brady O, Gething P, Bhatt S, Messina J, Brownstein J, Hoen A . Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Negl Trop Dis. 2012; 6(8):e1760. PMC: 3413714. DOI: 10.1371/journal.pntd.0001760. View

20.

Chretien J, Anyamba A, Small J, Britch S, Sanchez J, Halbach A . Global climate anomalies and potential infectious disease risks: 2014-2015. PLoS Curr. 2015; 7. PMC: 4323421. DOI: 10.1371/currents.outbreaks.95fbc4a8fb4695e049baabfc2fc8289f. View