Regulation of Maintenance DNA Methylation Via Histone Ubiquitylation

Overview

Journal J Biochem

Publisher Oxford University Press

Specialty Biochemistry

Date 2015 Nov 22

PMID 26590302

Citations 16

Authors

Atsuya Nishiyama

Luna Yamaguchi

Makoto Nakanishi

Affiliations

Soon will be listed here.

Abstract

DNA methylation is one of the most stable but dynamically regulated epigenetic marks that act as determinants of cell fates during embryonic development through regulation of various forms of gene expression. DNA methylation patterns must be faithfully propagated throughout successive cell divisions in order to maintain cell-specific function. We have recently demonstrated that Uhrf1-dependent ubiquitylation of histone H3 at lysine 23 is critical for Dnmt1 recruitment to DNA replication sites, which catalyzes the conversion of hemi-methylated DNA to fully methylated DNA. In this review, we provide an overview of recent progress in understanding the mechanism underlying maintenance DNA methylation.

Citing Articles

Tissue-specific roles of de novo DNA methyltransferases.

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Decoding histone ubiquitylation.

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The multi-functionality of UHRF1: epigenome maintenance and preservation of genome integrity.

Mancini M, Magnani E, Macchi F, Bonapace I Nucleic Acids Res. 2021; 49(11):6053-6068.

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