Posthepatectomy Liver Failure Affects Long-Term Function After Resection for Hepatocellular Carcinoma

Overview

Journal World J Surg

Publisher Wiley

Specialty General Surgery

Date 2015 Nov 22

PMID 26589593

Citations 6

Authors

Naohiko Nakamura

Etsuro Hatano

Kohta Iguchi

Satoru Seo

Kojiro Taura

Shinji Uemoto

Affiliations

Soon will be listed here.

Abstract

Background: This study examined whether the severity of posthepatectomy liver failure (PLF) affected the long-term postoperative liver recovery of patients with hepatocellular carcinoma (HCC).

Methods: We performed a retrospective cohort study of 395 HCC patients who underwent hepatectomy from 2004 to 2012 at the Kyoto University Hospital. The severity of PLF between postoperative days 5 and 10 was categorized according to the International Study Group of Liver Surgery criteria. We compared the Child-Pugh (C-P) score, platelet count (PLT), and the ratio of future remnant liver volume (FRLV) to the total liver volume (%RLV) at 3, 6, and 12 months after hepatectomy in the non-PLF, grade A, and grade B groups.

Results: The non-PLF, grade A, and grade B groups contained 272, 63, and 56 patients, respectively. The C-P score in the grade A group recovered from 5.37 points before hepatectomy to 5.38 points at 12 months after hepatectomy. The C-P score in the grade B group increased from 5.51 to 6.81 points at 3 months and was significantly higher (6.00 points) at 12 months than in the non-PLF group (5.47 points). The PLT significantly decreased at 12 months in the grade B group compared with the non-PLF group. The %RLV at 12 months in the non-PLF, grade A, and grade B groups were 84, 83, and 78 %, respectively. The remnant liver hypertrophy in the grade B group was significantly slower than that in the non-PLF group.

Conclusions: PLF severity affects long-term liver function recovery and remnant liver hypertrophy after hepatectomy.

Citing Articles

Albumin-Bilirubin Score at Post-Hepatectomy Hepatocellular Carcinoma Recurrence: Impact on Survival and Association with Post-Hepatectomy Liver Failure.

Horie H, Ogiso S, Yoh T, Fukumitsu K, Ishii T, Omae K J Gastrointest Surg. 2023; 27(11):2414-2423.

PMID: 37592191 DOI: 10.1007/s11605-023-05802-w.

CD4CD25 regulatory T cells decreased future liver remnant after associating liver partition and portal vein ligation for staged hepatectomy.

Wang W, Ye C, Deng Z, Wang J, Zhang L, Bao L World J Gastrointest Surg. 2023; 15(5):917-930.

PMID: 37342857 PMC: 10277939. DOI: 10.4240/wjgs.v15.i5.917.

Re-Rising of Total Bilirubin Level after Postoperative Day 3 (The V Pattern) Predicting Liver Failure and Survival of Patients who Underwent Hepatectomy for Cholangiocarcinoma.

Sawangkajohn W, Luvria V, Leeratanakachorn N, Tipwaratorn T, Theerakul S, Jarearnrat A Asian Pac J Cancer Prev. 2020; 21(12):3573-3578.

PMID: 33369454 PMC: 8046309. DOI: 10.31557/APJCP.2020.21.12.3573.

Evaluation of liver regeneration and post-hepatectomy liver failure after hemihepatectomy in patients with hepatocellular carcinoma.

Gong W, Zhong J, Lu Z, Zhang Q, Zhang Z, Chen C Biosci Rep. 2019; 39(8).

PMID: 31383787 PMC: 6706596. DOI: 10.1042/BSR20190088.

Clinical significance of post-hepatectomy hepatic failure in patients with liver metastases from colorectal cancer.

Jo H, Kim D, Jung S, Yu Y, Choi S, Kim W Ann Hepatobiliary Pancreat Surg. 2018; 22(2):93-100.

PMID: 29896569 PMC: 5981151. DOI: 10.14701/ahbps.2018.22.2.93.

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