Molecular and Epidemiological Studies of Porcine Rubulavirus Infection - an Overview

Overview

Journal Infect Ecol Epidemiol

Specialty Microbiology

Date 2015 Nov 21

PMID 26584829

Citations 4

Authors

Julieta Sandra Cuevas-Romero

Anne-Lie Blomstrom

Mikael Berg

Affiliations

Soon will be listed here.

Abstract

Porcine rubulavirus-La Piedad-Michoacan-Mexico virus (PorPV-LPMV) was identified as the causative agent of a viral disease that emerged spontaneously in Mexican swine in the 1980s. Since the report of the initial outbreak of the disease, only one full-length genome from a strain isolated in 1984 (PorPV-LPMV/1984) has been sequenced; sequence data are scarce from other isolates. The genetic variation of this virus that has spread throughout the main endemic region of Mexico is almost a complete mystery. The development of molecular techniques for improved diagnostics and to investigate the persistence, molecular epidemiology, and the possible reservoirs of PorPV are needed. Together, this will provide greater knowledge regarding the molecular genetic changes and useful data to establish new strategies in the control of this virus in Mexico.

Citing Articles

Immunogenicity of a recombinant hemagglutinin neuraminidase-Porcine rubulavirus produced by Escherichia coli of Porcine rubulavirus gives protective immunity of litter after challenge.

Cuevas-Romero J, Cerriteno-Sanchez J, Lara-Romero R, Vega-Lopez M, Ramirez-Estudillo C, Ramirez-Mendoza H J Vet Med Sci. 2022; 84(12):1595-1604.

PMID: 36273875 PMC: 9791230. DOI: 10.1292/jvms.22-0207.

Rapid protein sequence evolution via compensatory frameshift is widespread in RNA virus genomes.

Park D, Hahn Y BMC Bioinformatics. 2021; 22(1):251.

PMID: 34000995 PMC: 8127213. DOI: 10.1186/s12859-021-04182-9.

Immunoinformatics approach for predicting epitopes in HN and F proteins of Porcine rubulavirus.

Sianez-Estrada L, Rivera-Benitez J, Rosas-Murrieta N, Reyes-Leyva J, Santos-Lopez G, Herrera-Camacho I PLoS One. 2020; 15(9):e0239785.

PMID: 32976525 PMC: 7518572. DOI: 10.1371/journal.pone.0239785.

Zoonotic Potential of Emerging Paramyxoviruses: Knowns and Unknowns.

Thibault P, Watkinson R, Moreira-Soto A, Drexler J, Lee B Adv Virus Res. 2017; 98:1-55.

PMID: 28433050 PMC: 5894875. DOI: 10.1016/bs.aivir.2016.12.001.

References

Belak S, Thoren P . Molecular diagnosis of animal diseases: some experiences over the past decade. Expert Rev Mol Diagn. 2002; 1(4):434-43. DOI: 10.1586/14737159.1.4.434. View

Hernandez J, Reyes-Leyva J, ZENTENO R, Ramirez H, Hernandez-Jauregui P, Zenteno E . Immunity to porcine rubulavirus infection in adult swine. Vet Immunol Immunopathol. 1998; 64(4):367-81. DOI: 10.1016/s0165-2427(98)00169-x. View

Rivera-Benitez J, Cuevas-Romero S, Perez-Torres A, Reyes-Leyva J, Hernandez J, Ramirez-Mendoza H . Respiratory disease in growing pigs after Porcine rubulavirus experimental infection. Virus Res. 2013; 176(1-2):137-43. DOI: 10.1016/j.virusres.2013.05.017. View

Stephan H, Gay G, Ramirez T . Encephalomyelitis, reproductive failure and corneal opacity (blue eye) in pigs, associated with a paramyxovirus infection. Vet Rec. 1988; 122(1):6-10. DOI: 10.1136/vr.122.1.6. View

Hjertner B, Wiman A, Svenda M, Berg M, Moreno-Lopez J, Linne T . Multiple factors including subgenomic RNAs and reduced viral protein expression are associated with a persistent infection by porcine rubulavirus (LPMV). Arch Virol. 1998; 143(3):425-39. DOI: 10.1007/s007050050300. View

Ramirez-Mendoza H, Hernandez-Jauregui P, Reyes-Leyva J, Zenteno E, Moreno-Lopez J, Kennedy S . Lesions in the reproductive tract of boars experimentally infected with porcine rubulavirus. J Comp Pathol. 1998; 117(3):237-52. DOI: 10.1016/s0021-9975(97)80018-7. View

Vallejo V, Reyes-Leyva J, Hernandez J, Ramirez H, Delannoy P, Zenteno E . Differential expression of sialic acid on porcine organs during the maturation process. Comp Biochem Physiol B Biochem Mol Biol. 2000; 126(3):415-24. PMC: 7129425. DOI: 10.1016/s0305-0491(00)00213-3. View

Rodriguez-Ropon A, Hernandez-Jauregui P, Sanchez-Torres L, Favila-Castillo L, Estrada-Parra S, Moreno-Lopez J . Apoptosis in lymph nodes and changes in lymphocyte subpopulations in peripheral blood of pigs infected with porcine rubulavirus. J Comp Pathol. 2003; 128(1):1-8. DOI: 10.1053/jcpa.2002.0598. View

Wiman A, Hjertner B, Linne T, Herron B, Allan G, McNeilly F . Porcine rubulavirus LPMV RNA persists in the central nervous system of pigs after recovery from acute infection. J Neurovirol. 1998; 4(5):545-52. DOI: 10.3109/13550289809113499. View

10.

Moreno-Lopez J, Martinez A, Ericsson A . Characterization of a paramyxovirus isolated from the brain of a piglet in Mexico. Arch Virol. 1986; 91(3-4):221-31. DOI: 10.1007/BF01314282. View

11.

Solis M, Ramirez-Mendoza H, Mercado C, Espinosa S, Vallejo V, Reyes-Leyva J . Semen alterations in porcine rubulavirus-infected boars are related to viral excretion and have implications for artificial insemination. Res Vet Sci. 2007; 83(3):403-9. DOI: 10.1016/j.rvsc.2007.01.018. View

12.

Hjertner B, Linne T, Moreno-Lopez J . Establishment and characterisation of a porcine rubulavirus (LPMV) persistent infection in porcine kidney cells. Acta Vet Scand. 1997; 38(3):213-24. PMC: 8057016. View

13.

Mori I, Komatsu T, Takeuchi K, Nakakuki K, Sudo M, Kimura Y . Parainfluenza virus type 1 infects olfactory neurons and establishes long-term persistence in the nerve tissue. J Gen Virol. 1995; 76 ( Pt 5):1251-4. DOI: 10.1099/0022-1317-76-5-1251. View

14.

Allan G, McNeilly F, Walker I, Linne T, Moreno-Lopez J, Hernandez P . A sequential study of experimental porcine paramyxovirus (LPMV) infection of pigs: immunostaining of cryostat sections and virus isolation. J Vet Diagn Invest. 1996; 8(4):405-13. DOI: 10.1177/104063879600800401. View

15.

Nordengrahn A, Svenda M, Moreno-Lopez J, Bergvall A, Hernandez P, McNeilly F . Development of a blocking ELISA for screening antibodies to porcine rubulavirus, La Piedad Michoacan Virus. J Vet Diagn Invest. 1999; 11(4):319-23. DOI: 10.1177/104063879901100404. View

16.

Cuevas J, Rodriguez-Ropon A, Kennedy S, Moreno-Lopez J, Berg M, Hernandez-Jauregui P . Investigation of T-cell responses and viral mRNA persistence in lymph nodes of pigs infected with porcine rubulavirus. Vet Immunol Immunopathol. 2008; 127(1-2):148-52. DOI: 10.1016/j.vetimm.2008.09.008. View

17.

Berg M, Sundqvist A, Moreno-Lopez J, Linne T . Identification of the porcine paramyxovirus LPMV matrix protein gene: comparative sequence analysis with other paramyxoviruses. J Gen Virol. 1991; 72 ( Pt 5):1045-50. DOI: 10.1099/0022-1317-72-5-1045. View

18.

Wang L, Hansson E, Yu M, Chua K, Mathe N, Crameri G . Full-length genome sequence and genetic relationship of two paramyxoviruses isolated from bat and pigs in the Americas. Arch Virol. 2007; 152(7):1259-71. PMC: 7086891. DOI: 10.1007/s00705-007-0959-4. View

19.

Berg M, Hjertner B, Moreno-Lopez J, Linne T . The P gene of the porcine paramyxovirus LPMV encodes three possible polypeptides P, V and C: the P protein mRNA is edited. J Gen Virol. 1992; 73 ( Pt 5):1195-200. DOI: 10.1099/0022-1317-73-5-1195. View

20.

McNeilly F, Walker I, Allan G, Foster J, Linne T, Merza M . A comparative study on the use of virus and antibody detection techniques for the diagnosis of La Piedad Michoacan paramyxovirus (LPMV) infection in pigs. J Vet Diagn Invest. 1997; 9(1):3-9. DOI: 10.1177/104063879700900102. View