Regulating Factors in Acid-Sensing Ion Channel 1a Function

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2015 Nov 20

PMID 26582234

Citations 7

Authors

Yinghong Wang

Zaven OBryant

Huan Wang

Yan Huang

Affiliations

Soon will be listed here.

Abstract

In recent years, research of acid sensing ion channels (ASICs) has increased tremendously, especially studies focusing on ASIC1a, which plays a critical role in many important physiologic and pathological functions. This review will discuss factors regulating ASIC1a expression and activity in various conditions and will provide a theoretical basis for clinical development and application of ASIC1a modifiers.

Citing Articles

Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects.

Verkest C, Salinas M, Diochot S, Deval E, Lingueglia E, Baron A Toxins (Basel). 2022; 14(10).

PMID: 36287977 PMC: 9612379. DOI: 10.3390/toxins14100709.

The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target.

Wang Y, Hu X, Sun Y, Huang Y Front Pharmacol. 2022; 13:942209.

PMID: 35873582 PMC: 9304623. DOI: 10.3389/fphar.2022.942209.

Signaling Pathways in Proton and Non-proton ASIC1a Activation.

Castellanos L, Uchitel O, Weissmann C Front Cell Neurosci. 2021; 15:735414.

PMID: 34675777 PMC: 8523820. DOI: 10.3389/fncel.2021.735414.

Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis.

Xu Y, Chen F Front Immunol. 2021; 11:580936.

PMID: 33584647 PMC: 7876322. DOI: 10.3389/fimmu.2020.580936.

Antagonistic Effects of Tetramethylpyrazine on Hypoxic Respiratory Depression in Rats.

Li L, Gao B, Liu M Evid Based Complement Alternat Med. 2020; 2020:6456017.

PMID: 33062018 PMC: 7542524. DOI: 10.1155/2020/6456017.

References

Chao J, Woodley C, Chao L, Margolius H . Identification of tissue kallikrein in brain and in the cell-free translation product encoded by brain mRNA. J Biol Chem. 1983; 258(24):15173-8. View

Baron A, Schaefer L, Lingueglia E, Champigny G, Lazdunski M . Zn2+ and H+ are coactivators of acid-sensing ion channels. J Biol Chem. 2001; 276(38):35361-7. DOI: 10.1074/jbc.M105208200. View

Maurice T, Su T . The pharmacology of sigma-1 receptors. Pharmacol Ther. 2009; 124(2):195-206. PMC: 2785038. DOI: 10.1016/j.pharmthera.2009.07.001. View

Cho J, Askwith C . Potentiation of acid-sensing ion channels by sulfhydryl compounds. Am J Physiol Cell Physiol. 2007; 292(6):C2161-74. DOI: 10.1152/ajpcell.00598.2006. View

Brockway L, Zhou Z, Bubien J, Jovov B, Benos D, Keyser K . Rabbit retinal neurons and glia express a variety of ENaC/DEG subunits. Am J Physiol Cell Physiol. 2002; 283(1):C126-34. DOI: 10.1152/ajpcell.00457.2001. View

Li M, Inoue K, Branigan D, Kratzer E, Hansen J, Chen J . Acid-sensing ion channels in acidosis-induced injury of human brain neurons. J Cereb Blood Flow Metab. 2010; 30(6):1247-60. PMC: 2916164. DOI: 10.1038/jcbfm.2010.30. View

Khansari P, Halliwell R . Evidence for neuroprotection by the fenamate NSAID, mefenamic acid. Neurochem Int. 2009; 55(7):683-8. DOI: 10.1016/j.neuint.2009.06.014. View

Wang W, Yu Y, Xu T . Modulation of acid-sensing ion channels by Cu(2+) in cultured hypothalamic neurons of the rat. Neuroscience. 2007; 145(2):631-41. DOI: 10.1016/j.neuroscience.2006.12.009. View

Diochot S, Baron A, Rash L, Deval E, Escoubas P, Scarzello S . A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons. EMBO J. 2004; 23(7):1516-25. PMC: 391081. DOI: 10.1038/sj.emboj.7600177. View

10.

Sun X, Jin J, Zhang J, Qi L, Braun F, Zhang X . Expression of acid-sensing ion channels in nucleus pulposus cells of the human intervertebral disk is regulated by non-steroid anti-inflammatory drugs. Acta Biochim Biophys Sin (Shanghai). 2014; 46(9):774-81. PMC: 4207880. DOI: 10.1093/abbs/gmu067. View

11.

Diochot S, Baron A, Salinas M, Douguet D, Scarzello S, Dabert-Gay A . Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature. 2012; 490(7421):552-5. DOI: 10.1038/nature11494. View

12.

Baron A, Diochot S, Salinas M, Deval E, Noel J, Lingueglia E . Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels. Toxicon. 2013; 75:187-204. DOI: 10.1016/j.toxicon.2013.04.008. View

13.

Saez N, Mobli M, Bieri M, Chassagnon I, Malde A, Gamsjaeger R . A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a. Mol Pharmacol. 2011; 80(5):796-808. DOI: 10.1124/mol.111.072207. View

14.

Coryell M, Ziemann A, Westmoreland P, Haenfler J, Kurjakovic Z, Zha X . Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit. Biol Psychiatry. 2007; 62(10):1140-8. DOI: 10.1016/j.biopsych.2007.05.008. View

15.

Wemmie J, Price M, Welsh M . Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci. 2006; 29(10):578-86. DOI: 10.1016/j.tins.2006.06.014. View

16.

Sherwood T, Lee K, Gormley M, Askwith C . Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death. J Neurosci. 2011; 31(26):9723-34. PMC: 3160670. DOI: 10.1523/JNEUROSCI.1665-11.2011. View

17.

Hecquet C, Tan F, Marcic B, Erdos E . Human bradykinin B(2) receptor is activated by kallikrein and other serine proteases. Mol Pharmacol. 2000; 58(4):828-36. DOI: 10.1124/mol.58.4.828. View

18.

Xiong Z, Chu X, Simon R . Ca2+ -permeable acid-sensing ion channels and ischemic brain injury. J Membr Biol. 2006; 209(1):59-68. DOI: 10.1007/s00232-005-0840-x. View

19.

Salinas M, Besson T, Delettre Q, Diochot S, Boulakirba S, Douguet D . Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a. J Biol Chem. 2014; 289(19):13363-73. PMC: 4036345. DOI: 10.1074/jbc.M114.561076. View

20.

Wang W, Duan B, Xu H, Xu L, Xu T . Calcium-permeable acid-sensing ion channel is a molecular target of the neurotoxic metal ion lead. J Biol Chem. 2005; 281(5):2497-505. DOI: 10.1074/jbc.M507123200. View