Preoperative Enteral Nutritional Support in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma: A Strengthening the Reporting of Observational Studies in Epidemiology Article

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2015 Nov 19

PMID 26579806

Citations 11

Authors

Hui Yao

Xiaojie Bian

Liang Mao

Xuejian Zi

Xiaopeng Yan

Yudong Qiu

Affiliations

Soon will be listed here.

Abstract

To compare the short-term outcomes between hepatocellular carcinoma (HCC) patients with and those without preoperative nutrition on the basis of postoperative enteral nutrition.HCC patients with postoperative enteral nutrition who underwent liver resection between February 2010 and December 2014 in Nanjing Drum Tower Hospital were considered for the study: 43 patients with and 36 patients without preoperative nutrition. Primary endpoint was the incidence of overall complications. Secondary endpoints were infectious and major complications.In the preoperative enteral nutrition group, shorter length of postoperative hospital stay (10.5 ± 2.7 versus 13.7 ± 6.3 days, P = 0.007), less exogenous albumin infusion (10.2 ± 22.4 versus 47.8 ± 97.7 g, P = 0.030), earlier first exhaust time (2.7 ± 0.8 versus 3.0 ± 0.9 days, P = 0.043), and first defection time (3.5 ± 0.9 versus 4.4 ± 1.4 days, P = 0.001) were observed. No significant differences were observed in the incidence of overall complications (32.6% versus 52.8%, P = 0.070), infectious complications (7.0% versus 8.3%, P = 1), and major complications (14.0% versus 11.1%, P = 0.969) between the preoperative enteral nutrition and control group.Preoperative enteral nutrition could improve short-term outcomes of HCC patients via accelerating the recovery of gastrointestinal function and shortening the length of postoperative hospital stay.

Citing Articles

Perioperative oral nutritional support for patients diagnosed with primary colon adenocarcinoma undergoing radical surgical procedures -Peri-Nutri Trial: study protocol for a randomized controlled trial.

Aro R, Ohtonen P, Rautio T, Saarnio J, Makarainen E, Haivala R BMC Nutr. 2022; 8(1):89.

PMID: 36050804 PMC: 9438122. DOI: 10.1186/s40795-022-00591-y.

An Analysis of Individual and Contextual-Level Disparities in Screening, Treatment, and Outcomes for Hepatocellular Carcinoma.

Kronenfeld J, Goel N J Hepatocell Carcinoma. 2021; 8:1209-1219.

PMID: 34611524 PMC: 8487287. DOI: 10.2147/JHC.S284430.

Hepatocellular carcinoma in non-alcoholic fatty liver disease-a review of an emerging challenge facing clinicians.

Geh D, Manas D, Reeves H Hepatobiliary Surg Nutr. 2021; 10(1):59-75.

PMID: 33575290 PMC: 7867726. DOI: 10.21037/hbsn.2019.08.08.

The prognostic impact of lymphocyte-to-C-reactive protein score in patients undergoing surgical resection for intrahepatic cholangiocarcinoma: A comparative study of major representative inflammatory / immunonutritional markers.

Noguchi D, Kuriyama N, Nakagawa Y, Maeda K, Shinkai T, Gyoten K PLoS One. 2021; 16(1):e0245946.

PMID: 33507925 PMC: 7842956. DOI: 10.1371/journal.pone.0245946.

Prognostic Nutritional Index Considering Resection Range Is Useful for Predicting Postoperative Morbidity of Hepatectomy.

Nagata S, Maeda S, Nagamatsu S, Kai S, Fukuyama Y, Korematsu S J Gastrointest Surg. 2021; 25(11):2788-2795.

PMID: 33420654 PMC: 8602222. DOI: 10.1007/s11605-020-04893-z.

References

Srinivasa S, Singh S, Kahokehr A, Taylor M, Hill A . Perioperative fluid therapy in elective colectomy in an enhanced recovery programme. ANZ J Surg. 2012; 82(7-8):535-40. DOI: 10.1111/j.1445-2197.2012.06122.x. View

Braga M, Ljungqvist O, Soeters P, Fearon K, Weimann A, Bozzetti F . ESPEN Guidelines on Parenteral Nutrition: surgery. Clin Nutr. 2009; 28(4):378-86. DOI: 10.1016/j.clnu.2009.04.002. View

Wilmore D, Kehlet H . Management of patients in fast track surgery. BMJ. 2001; 322(7284):473-6. PMC: 1119685. DOI: 10.1136/bmj.322.7284.473. View

Li G, Ren J, Wang G, Hu D, Gu G, Liu S . Preoperative exclusive enteral nutrition reduces the postoperative septic complications of fistulizing Crohn's disease. Eur J Clin Nutr. 2014; 68(4):441-6. DOI: 10.1038/ejcn.2014.16. View

Ramacciato G, DAngelo F, Baldini R, Petrucciani N, Antolino L, Aurello P . Hepatocellular carcinomas and primary liver tumors as predictive factors for postoperative mortality after liver resection: a meta-analysis of more than 35,000 hepatic resections. Am Surg. 2012; 78(4):456-67. View

Sungurtekin H, Sungurtekin U, Balci C, Zencir M, Erdem E . The influence of nutritional status on complications after major intraabdominal surgery. J Am Coll Nutr. 2004; 23(3):227-32. DOI: 10.1080/07315724.2004.10719365. View

Dong J, Yang S, Zeng J, Cai S, Ji W, Duan W . Precision in liver surgery. Semin Liver Dis. 2013; 33(3):189-203. DOI: 10.1055/s-0033-1351781. View

Forner A, Llovet J, Bruix J . Hepatocellular carcinoma. Lancet. 2012; 379(9822):1245-55. DOI: 10.1016/S0140-6736(11)61347-0. View

Ni C, Yang Y, Chang Y, Cai H, Xu B, Yang F . Fast-track surgery improves postoperative recovery in patients undergoing partial hepatectomy for primary liver cancer: A prospective randomized controlled trial. Eur J Surg Oncol. 2013; 39(6):542-7. DOI: 10.1016/j.ejso.2013.03.013. View

10.

Rodriguez de Lope C, Tremosini S, Forner A, Reig M, Bruix J . Management of HCC. J Hepatol. 2012; 56 Suppl 1:S75-87. DOI: 10.1016/S0168-8278(12)60009-9. View

11.

Aida T, Furukawa K, Suzuki D, Shimizu H, Yoshidome H, Ohtsuka M . Preoperative immunonutrition decreases postoperative complications by modulating prostaglandin E2 production and T-cell differentiation in patients undergoing pancreatoduodenectomy. Surgery. 2014; 155(1):124-33. DOI: 10.1016/j.surg.2013.05.040. View

12.

Holst M, Rasmussen H, Irtun O . Advances in clinical nutrition in GI surgery. Expert Rev Gastroenterol Hepatol. 2014; 9(4):467-73. DOI: 10.1586/17474124.2015.972371. View

13.

Stoot J, M van Dam R, Busch O, van Hillegersberg R, De Boer M, Olde Damink S . The effect of a multimodal fast-track programme on outcomes in laparoscopic liver surgery: a multicentre pilot study. HPB (Oxford). 2009; 11(2):140-4. PMC: 2697877. DOI: 10.1111/j.1477-2574.2009.00025.x. View

14.

Nathan H, Hyder O, Mayo S, Hirose K, Wolfgang C, Choti M . Surgical therapy for early hepatocellular carcinoma in the modern era: a 10-year SEER-medicare analysis. Ann Surg. 2013; 258(6):1022-7. PMC: 3994667. DOI: 10.1097/SLA.0b013e31827da749. View

15.

Plauth M, Cabre E, Riggio O, Assis-Camilo M, Pirlich M, Kondrup J . ESPEN Guidelines on Enteral Nutrition: Liver disease. Clin Nutr. 2006; 25(2):285-94. DOI: 10.1016/j.clnu.2006.01.018. View

16.

Fang S, Long J, Tan R, Mai H, Lu W, Yan F . A multicentre assessment of malnutrition, nutritional risk, and application of nutritional support among hospitalized patients in Guangzhou hospitals. Asia Pac J Clin Nutr. 2013; 22(1):54-9. DOI: 10.6133/apjcn.2013.22.1.01. View

17.

Zacharias T, Ferreira N, Carin A . Preoperative immunonutrition in liver resection-a propensity score matched case-control analysis. Eur J Clin Nutr. 2014; 68(8):964-9. DOI: 10.1038/ejcn.2014.113. View

18.

. [Antibioprophylaxis in surgery and interventional medicine (adult patients). Actualization 2010]. Ann Fr Anesth Reanim. 2011; 30(2):168-90. DOI: 10.1016/j.annfar.2010.05.012. View

19.

Mizuguchi T, Nagayama M, Meguro M, Shibata T, Kaji S, Nobuoka T . Prognostic impact of surgical complications and preoperative serum hepatocyte growth factor in hepatocellular carcinoma patients after initial hepatectomy. J Gastrointest Surg. 2008; 13(2):325-33. DOI: 10.1007/s11605-008-0711-8. View

20.

Cucchetti A, Qiao G, Cescon M, Li J, Xia Y, Ercolani G . Anatomic versus nonanatomic resection in cirrhotic patients with early hepatocellular carcinoma. Surgery. 2014; 155(3):512-21. DOI: 10.1016/j.surg.2013.10.009. View