Antimalarial Properties of Ebselen

Overview

Journal Parasitol Res

Specialty Parasitology

Date 1989 Jan 1

PMID 2657716

Citations 7

Authors

A M Huther

Y Zhang

A Sauer

M J Parnham

Affiliations

Soon will be listed here.

Abstract

The seleno-organic compound ebselen showed anti-malarial activity in vitro against the murine Plasmodium berghei and the human P. falciparum. In P. berghei, the uptake and incorporation of [3H]-methionine and [3H]-adenosine was inhibited and the infectivity of plasmodia was reduced. Ebselen affects the development of asexual stages of chloroquine-resistant and -sensitive P. falciparum strains. Its IC50 for P. falciparum was about 14 mumol/l and that for P. berghei, about 10 mumol/l. The growth of P. falciparum was blocked by ebselen at all stages, including the invasion of erythrocytes by merozoites. In a human hepatoma cell line and in mouse peritoneal macrophages, no cytostatic or cytotoxic effects were found, indicating selective inhibition of plasmodia by ebselen. Its in vitro inhibitory effect is discussed in relation to its possible reactivity with thiol groups and its lack of an anti-malarial effect in infected mice.

Citing Articles

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Ebselen, a new candidate therapeutic against SARS-CoV-2.

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Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System.

May H, Yu J, Guentzel M, Chambers J, Cap A, Arulanandam B Front Microbiol. 2018; 9:336.

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Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways.

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PMID: 24867080 DOI: 10.1007/s11033-014-3417-x.

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