Haemophagocytic Lymphohistiocytosis in Inflammatory Bowel Disease with Virus Infection

Overview

Journal Prz Gastroenterol

Publisher Termedia

Specialty Gastroenterology

Date 2015 Nov 12

PMID 26557937

Citations 4

Authors

Yuan Li

Xuefeng Xia

Jing Zhang

Zhiqiang Song

Liya Zhou

Yaopeng Zhang

Yonghui Huang

Yanyan Shi

Eamonn M M Quigley

Shigang Ding

Affiliations

Soon will be listed here.

Abstract

Patients with inflammatory bowel disease (IBD) are at risk of developing haemophagocytic lymphohistiocytosis (HLH) because of chronic systemic inflammation as well as exposure to immunosuppressive medications. The two main causes of HLH in IBD patients are infection with cytomegalovirus and Epstein-Barr virus. Patients with Crohn's disease are more susceptible to HLH than those with ulcerative colitis. The majority of cases are seen in people receiving an immunosuppressive regimen that included thiopurines.

Citing Articles

An Elusive Diagnosis: Case Reports of Secondary Hemophagocytic Lymphohistiocytosis and Review of Current Literature.

Tong Q, Godbole M, Biniwale N, Jamshed S Cureus. 2019; 11(4):e4548.

PMID: 31275772 PMC: 6592840. DOI: 10.7759/cureus.4548.

Hemophagocytic Lymphohistiocytosis Secondary to Unknown Underlying Hodgkin Lymphoma Presenting with a Cholestatic Pattern of Liver Injury.

Booth A, Osehobo P, Rodgers-Soriano D, Lalarukh A, Eltorky M, Stevenson H Case Rep Gastroenterol. 2018; 12(1):99-108.

PMID: 29805352 PMC: 5968292. DOI: 10.1159/000486190.

Gastrointestinal Disorders Associated with Primary Immunodeficiency Diseases.

Hartono S, Ippoliti M, Mastroianni M, Torres R, Rider N Clin Rev Allergy Immunol. 2018; 57(2):145-165.

PMID: 29754192 DOI: 10.1007/s12016-018-8689-9.

Crohn's disease complicated by Epstein-Barr virus-driven haemophagocytic lymphohistiocytosis successfully treated with rituximab.

Thompson G, Pepperell D, Lawrence I, McGettigan B BMJ Case Rep. 2017; 2017.

PMID: 28228435 PMC: 5337688. DOI: 10.1136/bcr-2016-218578.

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