Expression of Th17 Cell Population Regulatory Cytokines in Laryngeal Carcinoma - Preliminary Study

Overview

Journal Contemp Oncol (Pozn)

Publisher Termedia

Specialty Oncology

Date 2015 Nov 12

PMID 26557759

Citations 1

Authors

Renata Kopta

Marcin Mochocki

Piotr Morawski

Ewa Brzezinska-Blaszczyk

Iwona Lewy-Trenda

Katarzyna Starska

Affiliations

Soon will be listed here.

Abstract

Aim Of The Study: Aim of the study was to evaluate the potential role of regulatory and proinflammatory cytokines IL-23 and IL-17 as Th17 lymphocyte activity markers in relation to invasiveness in laryngeal cancer.

Material And Methods: The immunological analysis was conducted in 50 patients treated for squamous cell laryngeal carcinoma and 30 healthy volunteers as controls. The levels of IL-23 and IL-17 in supernatants of purified peripheral blood mononuclear cell cultures were determined by using the enzyme-linked immunosorbent assay (ELISA). The clinicomorphological criteria included pTNM, stage, G, and the total tumour front grading (TFG) score.

Results: Our data demonstrated higher concentrations of IL-23 in patients as compared to controls (p = 0.0001). No statistical difference for IL-17 in these groups was observed. Our study revealed significant dependences in IL-23 expression on pT (p = 0.04), histological differentiation (p = 0.04), and TFG total score (p = 0.02). Advanced tumours (pT3-pT4) with higher grade (G2-G3) and higher invasiveness (> 14 TFG points) were characterised by elevated IL-23 levels in PBMC supernatants. Our data did not indicate a relationship between cytokine levels and three- and five-year survival. However, a tendency towards lower content of IL-23 in PBMC cultures in patients who lived longer than five years after treatment was noted. The relationships between IL-17 level in PBMC cultures and clinicomorphological and prognostic parameters have not been disclosed.

Conclusions: The results of this study suggest the importance of regulatory cytokine IL-23 in determining the aggressive potential of laryngeal carcinomas.

Citing Articles

IL-17 Affects the Progression, Metastasis, and Recurrence of Laryngeal Cancer the Inhibition of Apoptosis through Activation of the PI3K/AKT/FAS/FASL Pathways.

Song Y, Yang M, Zhang H, Sun Y, Tao Y, Li H J Immunol Res. 2021; 2020:2953191.

PMID: 33415169 PMC: 7769679. DOI: 10.1155/2020/2953191.

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