Satellite Cells in Human Skeletal Muscle Plasticity

Overview

Journal Front Physiol

Date 2015 Nov 12

PMID 26557092

Citations 150

Authors

Tim Snijders

Joshua P Nederveen

Bryon R McKay

Sophie Joanisse

Lex B Verdijk

Luc J C van Loon

Gianni Parise

Affiliations

Soon will be listed here.

Abstract

Skeletal muscle satellite cells are considered to play a crucial role in muscle fiber maintenance, repair and remodeling. Our knowledge of the role of satellite cells in muscle fiber adaptation has traditionally relied on in vitro cell and in vivo animal models. Over the past decade, a genuine effort has been made to translate these results to humans under physiological conditions. Findings from in vivo human studies suggest that satellite cells play a key role in skeletal muscle fiber repair/remodeling in response to exercise. Mounting evidence indicates that aging has a profound impact on the regulation of satellite cells in human skeletal muscle. Yet, the precise role of satellite cells in the development of muscle fiber atrophy with age remains unresolved. This review seeks to integrate recent results from in vivo human studies on satellite cell function in muscle fiber repair/remodeling in the wider context of satellite cell biology whose literature is largely based on animal and cell models.

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