Plantago Ovata F. Mucilage-Alginate Mucoadhesive Beads for Controlled Release of Glibenclamide: Development, Optimization, and In Vitro-In Vivo Evaluation

Overview

Journal J Pharm (Cairo)

Specialty Pharmacology

Date 2015 Nov 12

PMID 26555967

Citations 9

Authors

Amit Kumar Nayak

Dilipkumar Pal

Kousik Santra

Affiliations

Soon will be listed here.

Abstract

The current study deals with the development and optimization of ispaghula (Plantago ovata F.) husk mucilage- (IHM-) alginate mucoadhesive beads containing glibenclamide by ionotropic gelation technique. The effects of sodium alginate (SA) to IHM and cross-linker (CaCl2) concentration on the drug encapsulation efficiency (DEE, %), as well as cumulative drug release after 10 hours (R10 h, %), were optimized using 3(2) factorial design based on response surface methodology. The observed responses were coincided well with the predicted values by the experimental design. The optimized mucoadhesive beads exhibited 94.43 ± 4.80% w/w of DEE and good mucoadhesivity with the biological membrane in wash-off test and sustained drug release profile over 10 hours. The beads were also characterized by SEM and FTIR analyses. The in vitro drug release from these beads was followed by controlled release (zero-order) pattern with super case-II transport mechanism. The optimized glibenclamide-loaded IHM-alginate mucoadhesive beads showed significant antidiabetic effect in alloxan-induced diabetic rats over prolonged period after oral administration.

Citing Articles

Basil seed mucilage as a bioadhesive polymer: Development of naproxen sodium microspheres and suppositories with and studies.

Tripathi D, Rathour K, Pandey P, Kumar Tiwari R, Rai A ADMET DMPK. 2024; 12(6):881-901.

PMID: 39713257 PMC: 11661803. DOI: 10.5599/admet.2372.

Preparation and Evaluation of pH-Sensitive Chitosan/Alginate Nanohybrid Mucoadhesive Hydrogel Beads: An Effective Approach to a Gastro-Retentive Drug Delivery System.

Rehman S, Jamil Q, Noreen S, Ashraf M, Madni A, Mahmood H Pharmaceutics. 2024; 16(11).

PMID: 39598574 PMC: 11597505. DOI: 10.3390/pharmaceutics16111451.

Drug Delivery Application of Functional Nanomaterials Synthesized Using Natural Sources.

Veerapandian M, Ramasundaram S, Jerome P, Chellasamy G, Govindaraju S, Yun K J Funct Biomater. 2023; 14(8).

PMID: 37623670 PMC: 10455391. DOI: 10.3390/jfb14080426.

Recent developments in natural biopolymer based drug delivery systems.

Fazal T, Murtaza B, Shah M, Iqbal S, Rehman M, Jaber F RSC Adv. 2023; 13(33):23087-23121.

PMID: 37529365 PMC: 10388836. DOI: 10.1039/d3ra03369d.

In Vitro/In Vivo Evaluation of Clomipramine Orodispersible Tablets for the Treatment of Depression and Obsessive-Compulsive Disorder.

Ghumman S, Hameed H, Noreen S, Al-Hussain S, Kausar R, Irfan A Pharmaceuticals (Basel). 2023; 16(2).

PMID: 37259410 PMC: 9967651. DOI: 10.3390/ph16020265.

References

Nayak A, Khatua S, Hasnain M, Sen K . Development of diclofenac sodium-loaded alginate-PVP K 30 microbeads using central composite design. Daru. 2012; 19(5):356-66. PMC: 3304399. View

Yoo S, Song Y, Chang P, Lee H . Microencapsulation of alpha-tocopherol using sodium alginate and its controlled release properties. Int J Biol Macromol. 2006; 38(1):25-30. DOI: 10.1016/j.ijbiomac.2005.12.013. View

Joshi S, Chavhan S, Sawant K . Rivastigmine-loaded PLGA and PBCA nanoparticles: preparation, optimization, characterization, in vitro and pharmacodynamic studies. Eur J Pharm Biopharm. 2010; 76(2):189-99. DOI: 10.1016/j.ejpb.2010.07.007. View

Singh B, Dahiya M, Saharan V, Ahuja N . Optimizing drug delivery systems using systematic "design of experiments." Part II: retrospect and prospects. Crit Rev Ther Drug Carrier Syst. 2005; 22(3):215-94. DOI: 10.1615/critrevtherdrugcarriersyst.v22.i3.10. View

Sharma P, Koul A . Mucilage in seeds of Plantago ovata and its wild allies. J Ethnopharmacol. 1986; 17(3):289-95. DOI: 10.1016/0378-8741(86)90118-2. View

Singh B, Kapil R, Nandi M, Ahuja N . Developing oral drug delivery systems using formulation by design: vital precepts, retrospect and prospects. Expert Opin Drug Deliv. 2011; 8(10):1341-60. DOI: 10.1517/17425247.2011.605120. View

Singh B, Kumar R, Ahuja N . Optimizing drug delivery systems using systematic "design of experiments." Part I: fundamental aspects. Crit Rev Ther Drug Carrier Syst. 2005; 22(1):27-105. DOI: 10.1615/critrevtherdrugcarriersyst.v22.i1.20. View

Pal D, Nayak A . Development, optimization, and anti-diabetic activity of gliclazide-loaded alginate-methyl cellulose mucoadhesive microcapsules. AAPS PharmSciTech. 2011; 12(4):1431-41. PMC: 3225545. DOI: 10.1208/s12249-011-9709-8. View

Han J, Zhou Z, Yin R, Yang D, Nie J . Alginate-chitosan/hydroxyapatite polyelectrolyte complex porous scaffolds: preparation and characterization. Int J Biol Macromol. 2009; 46(2):199-205. DOI: 10.1016/j.ijbiomac.2009.11.004. View

10.

Llanes F, Ryan D, Marchessault R . Magnetic nanostructured composites using alginates of different M/G ratios as polymeric matrix. Int J Biol Macromol. 2000; 27(1):35-40. DOI: 10.1016/s0141-8130(99)00115-4. View

11.

Prajapati S, Tripathi P, Ubaidulla U, Anand V . Design and development of gliclazide mucoadhesive microcapsules: in vitro and in vivo evaluation. AAPS PharmSciTech. 2008; 9(1):224-30. PMC: 2976877. DOI: 10.1208/s12249-008-9041-0. View

12.

Pal D, Nayak A . Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery: in vitro-in vivo evaluation. Drug Deliv. 2012; 19(3):123-31. DOI: 10.3109/10717544.2012.657717. View

13.

Malakar J, Nayak A, Pal D . Development of cloxacillin loaded multiple-unit alginate-based floating system by emulsion-gelation method. Int J Biol Macromol. 2011; 50(1):138-47. DOI: 10.1016/j.ijbiomac.2011.10.001. View

14.

Nayak A, Das B, Maji R . Calcium alginate/gum Arabic beads containing glibenclamide: development and in vitro characterization. Int J Biol Macromol. 2012; 51(5):1070-8. DOI: 10.1016/j.ijbiomac.2012.08.021. View

15.

Saeedi M, Morteza-Semnani K, Ansoroudi F, Fallah S, Amin G . Evaluation of binding properties of Plantago psyllium seed mucilage. Acta Pharm. 2010; 60(3):339-48. DOI: 10.2478/v10007-010-0028-5. View

16.

Singh B . Psyllium as therapeutic and drug delivery agent. Int J Pharm. 2007; 334(1-2):1-14. DOI: 10.1016/j.ijpharm.2007.01.028. View

17.

Nayak A, Pal D . Development of pH-sensitive tamarind seed polysaccharide-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology. Int J Biol Macromol. 2011; 49(4):784-93. DOI: 10.1016/j.ijbiomac.2011.07.013. View

18.

Singh B, Garg B, Chaturvedi S, Arora S, Mandsaurwale R, Kapil R . Formulation development of gastroretentive tablets of lamivudine using the floating-bioadhesive potential of optimized polymer blends. J Pharm Pharmacol. 2012; 64(5):654-69. DOI: 10.1111/j.2042-7158.2011.01442.x. View

19.

Patel Y, Sher P, Pawar A . The effect of drug concentration and curing time on processing and properties of calcium alginate beads containing metronidazole by response surface methodology. AAPS PharmSciTech. 2007; 7(4):86. DOI: 10.1208/pt070486. View

20.

Sriamornsak P, Sungthongjeen S . Modification of theophylline release with alginate gel formed in hard capsules. AAPS PharmSciTech. 2007; 8(3):E51. PMC: 2750547. DOI: 10.1208/pt0803051. View