Circulating Progenitor Cells and Childhood Cardiovascular Disease

Overview

Journal Pediatr Cardiol

Specialties Cardiology & Vascular Diseases
Pediatrics

Date 2015 Nov 12

PMID 26554720

Citations 1

Authors

Eric J Kort

Lacey Croskey

Taryn Scibienski

Surender Rajasekaran

Stefan Jovinge

Affiliations

Soon will be listed here.

Abstract

Circulating progenitor cells have been extensively studied in the context of heart disease in adults. In these patients, they have been demonstrated to be markers of myocardial injury and recovery as well as potential therapeutic agents. However, studies in children are much more limited. Here we review current knowledge pertaining to circulating progenitor cells in the context of childhood cardiovascular disease. Priorities for further research are also highlighted.

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References

Peichev M, Naiyer A, Pereira D, Zhu Z, Lane W, Williams M . Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood. 2000; 95(3):952-8. View

Ostadal B, Ostadalova I, Kolar F, Charvatova Z, Netuka I . Ontogenetic development of cardiac tolerance to oxygen deprivation - possible mechanisms. Physiol Res. 2010; 58 Suppl 2:S1-12. DOI: 10.33549/physiolres.931920. View

Park J, Miyashita M, Kwon Y, Park H, Kim E, Park J . A 12-week after-school physical activity programme improves endothelial cell function in overweight and obese children: a randomised controlled study. BMC Pediatr. 2012; 12:111. PMC: 3447644. DOI: 10.1186/1471-2431-12-111. View

He T, Smith L, Harrington S, Nath K, Caplice N, Katusic Z . Transplantation of circulating endothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries. Stroke. 2004; 35(10):2378-84. DOI: 10.1161/01.STR.0000141893.33677.5d. View

Zhao Y, Courtman D, Deng Y, Kugathasan L, Zhang Q, Stewart D . Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ Res. 2005; 96(4):442-50. DOI: 10.1161/01.RES.0000157672.70560.7b. View

Xu M, Meng X, Li B, Liu C . The circulating level of endothelial progenitor cells after transcatheter closure of congenital heart disease in children. Pediatr Cardiol. 2013; 34(6):1344-9. DOI: 10.1007/s00246-013-0647-y. View

Flores-Ramirez R, Uribe-Longoria A, Rangel-Fuentes M, Gutierrez-Fajardo P, Salazar-Riojas R, Cervantes-Garcia D . Intracoronary infusion of CD133+ endothelial progenitor cells improves heart function and quality of life in patients with chronic post-infarct heart insufficiency. Cardiovasc Revasc Med. 2010; 11(2):72-8. DOI: 10.1016/j.carrev.2009.04.001. View

Kuliczkowski W, Derzhko R, Prajs I, Podolak-Dawidziak M, Serebruany V . Endothelial progenitor cells and left ventricle function in patients with acute myocardial infarction: potential therapeutic considertions. Am J Ther. 2010; 19(1):44-50. DOI: 10.1097/MJT.0b013e3181e0cab3. View

Qi Y, Jiang Q, Chen C, Cao Y, Qian L . Circulating endothelial progenitor cells decrease in infants with bronchopulmonary dysplasia and increase after inhaled nitric oxide. PLoS One. 2013; 8(11):e79060. PMC: 3823930. DOI: 10.1371/journal.pone.0079060. View

10.

Cabanelas N, Martins J, Pinto F . Initial use of endothelial progenitor cells capturing stents in paediatric congenital heart disease. Cardiol Young. 2013; 24(5):900-4. DOI: 10.1017/S1047951113001376. View

11.

Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T . Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997; 275(5302):964-7. DOI: 10.1126/science.275.5302.964. View

12.

Groner J, Huang H, Nagaraja H, Kuck J, Bauer J . Secondhand smoke exposure and endothelial stress in children and adolescents. Acad Pediatr. 2014; 15(1):54-60. PMC: 5133704. DOI: 10.1016/j.acap.2014.09.003. View

13.

Pham H, Patel N, Semedei-Pomales M, Bhatia M, Schwartz J . The use of plerixafor in hematopoietic progenitor cell collection in pediatric patients: a single center experience. Cytotherapy. 2012; 14(4):467-72. DOI: 10.3109/14653249.2012.658912. View

14.

Li C, Gaol R, Yang Y, Hu F, Yang W, You S . Effect of intracoronary infusion of bone marrow mononuclear cells or peripheral endothelial progenitor cells on myocardial ischemia-reperfusion injury in mini-swine. Chin Med Sci J. 2010; 25(3):176-81. DOI: 10.1016/s1001-9294(10)60044-2. View

15.

Dubois C, Liu X, Claus P, Marsboom G, Pokreisz P, Vandenwijngaert S . Differential effects of progenitor cell populations on left ventricular remodeling and myocardial neovascularization after myocardial infarction. J Am Coll Cardiol. 2010; 55(20):2232-43. DOI: 10.1016/j.jacc.2009.10.081. View

16.

Nygren J, Liuba K, Breitbach M, Stott S, Thoren L, Roell W . Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion. Nat Cell Biol. 2008; 10(5):584-92. DOI: 10.1038/ncb1721. View

17.

Schleicher M, Wendel H, Fritze O, Stock U . In vivo tissue engineering of heart valves: evolution of a novel concept. Regen Med. 2009; 4(4):613-9. DOI: 10.2217/rme.09.22. View

18.

Smadja D, Gaussem P, Mauge L, Israel-Biet D, Dignat-George F, Peyrard S . Circulating endothelial cells: a new candidate biomarker of irreversible pulmonary hypertension secondary to congenital heart disease. Circulation. 2009; 119(3):374-81. DOI: 10.1161/CIRCULATIONAHA.108.808246. View

19.

Cebotari S, Lichtenberg A, Tudorache I, Hilfiker A, Mertsching H, Leyh R . Clinical application of tissue engineered human heart valves using autologous progenitor cells. Circulation. 2006; 114(1 Suppl):I132-7. DOI: 10.1161/CIRCULATIONAHA.105.001065. View

20.

Kheirandish-Gozal L, Bhattacharjee R, Kim J, Clair H, Gozal D . Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apnea. Am J Respir Crit Care Med. 2010; 182(1):92-7. PMC: 2902761. DOI: 10.1164/rccm.200912-1845OC. View