Cancer and Its Association With the Development of Coronary Artery Calcification: An Assessment From the Multi-Ethnic Study of Atherosclerosis

Overview

Journal J Am Heart Assoc

Specialty Cardiology & Vascular Diseases

Date 2015 Nov 11

PMID 26553214

Citations 33

Authors

Matthew C Whitlock

Joseph Yeboah

Gregory L Burke

Haiying Chen

Heidi D Klepin

W Gregory Hundley

Affiliations

Soon will be listed here.

Abstract

Background: Although cancer and its corresponding therapies are associated with increased ischemic heart disease, the temporal relationship between cancer and the development of coronary artery calcium (CAC), a marker of subclinical atherosclerosis, is unknown.

Methods And Results: Among 3122 men and women free of cardiovascular disease and cancer in the Multi-Ethnic Study of Atherosclerosis trial, CAC scoring was performed at baseline (2000-2002) and at follow-up (2010-2012). Over this 10-year period, 85 men (age 63.6±8.3 years) and 50 women (age 62.1±9.8 years) were diagnosed with cancer (predominantly breast, lung, or uterine [52%] in women and prostate or colorectal [78%] in men). The other 2987 subjects (age 59.6±9.2 years for men, 59.7±9.4 years for women) remained cancer free. The incidence of new CAC (baseline Agatston score of zero converting to detectable CAC) was modeled with relative risk regression and compared for cancer versus no cancer. Increase in pre-existing CAC was compared in these groups using linear regression of log transformed CAC. The incidence of CAC was independently associated with cancer history (relative risk 1.32 [P=0.04] and 1.29 [P=0.01] for women and men, respectively). In participants with CAC at baseline, a clear difference of CAC progression was not observed between cancer and noncancer participants (P=0.6 for women, P=0.2 for men).

Conclusions: A diagnosis of cancer is associated with the development of CAC even after accounting for atherosclerotic risk factors. However, in individuals with pre-existing CAC, it is not clear whether the presence of cancer accelerates CAC over time.

Citing Articles

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PMID: 39518317 PMC: 11545064. DOI: 10.3390/diagnostics14212349.

Mechanisms of Myocardial Ischemia in Cancer Patients: A State-of-the-Art Review of Obstructive Versus Non-Obstructive Causes.

Balanescu D, Bloomingdale R, Donisan T, Yang E, Parwani P, Iliescu C Rev Cardiovasc Med. 2024; 23(7):227.

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Arterial Stiffness Changes in Adult Cancer Patients Receiving Anticancer Chemotherapy: A Real-World Bicentric Experience.

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Use of computed tomography coronary calcium score for prediction of cardiovascular events in cancer patients: a retrospective cohort analysis.

Patel S, Franco F, McDonald M, Rivera C, Perez-Villa B, Collier P Cardiooncology. 2024; 10(1):1.

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Long-term and real-life incidence of cancer therapy-related cardiovascular toxicity in patients with breast cancer: a Swedish cohort study.

Hubbert L, Mallios P, Karlstrom P, Papakonstantinou A, Bergh J, Hedayati E Front Oncol. 2023; 13:1095251.

PMID: 37152049 PMC: 10154463. DOI: 10.3389/fonc.2023.1095251.

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