» Articles » PMID: 2655186

Postischemic Insulin Reduces Spatial Learning Deficit Following Transient Forebrain Ischemia in Rats

Overview
Journal Stroke
Date 1989 May 1
PMID 2655186
Citations 16
Authors
Affiliations
Soon will be listed here.
Abstract

We investigated the ability of postischemic insulin administration to modify the structural and neurobehavioral consequences of cerebral ischemia in rats. Forebrain ischemia was induced in fed rats by combining controlled systemic hypotension with bilateral carotid artery clamping for 10 1/2 minutes. Following clamp release, one group of six rats [corrected] was given insulin (2 IU/kg s.c. b.i.d.) for 1 week. An ischemic-control group of five rats [corrected] received no postischemic treatment. A sham-ischemia group of rats was used as a behavioral control. Throughout the recovery period until sacrifice, the drinking water of all rats was supplemented with 25% glucose. Rats were trained on two water maze place navigation tasks 1-2 months after ischemia. Escape latencies and swim patterns were recorded. Performance in the insulin-treated group was better than that in the ischemic-control group (p less than 0.05) on both tasks and did not differ significantly from that of the sham-ischemia group. Improvement in behavior correlated with a significant reduction in CA1 hippocampal necrosis in the insulin-treated group (p less than 0.05). Our findings demonstrate that postischemic treatment with insulin improves neurobehavioral performance in addition to lessening ischemic neuronal necrosis.

Citing Articles

Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium.

Shpakov A, Zorina I, Derkach K Int J Mol Sci. 2023; 24(4).

PMID: 36834685 PMC: 9962062. DOI: 10.3390/ijms24043278.


Significance of Brain Glucose Hypometabolism, Altered Insulin Signal Transduction, and Insulin Resistance in Several Neurological Diseases.

Blazquez E, Hurtado-Carneiro V, LeBaut-Ayuso Y, Velazquez E, Garcia-Garcia L, Gomez-Oliver F Front Endocrinol (Lausanne). 2022; 13:873301.

PMID: 35615716 PMC: 9125423. DOI: 10.3389/fendo.2022.873301.


Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link.

Brzecka A, Madetko N, Nikolenko V, Ashraf G, Ejma M, Leszek J Curr Neuropharmacol. 2020; 19(1):78-91.

PMID: 32148197 PMC: 7903492. DOI: 10.2174/1570159X18666200309101750.


Insulin and Autophagy in Neurodegeneration.

Prudente de Mello N, Orellana A, Mazucanti C, Lima G, Scavone C, Kawamoto E Front Neurosci. 2019; 13:491.

PMID: 31231176 PMC: 6558407. DOI: 10.3389/fnins.2019.00491.


Nutrient-driven O-GlcNAc in proteostasis and neurodegeneration.

Akan I, Olivier-Van Stichelen S, Bond M, Hanover J J Neurochem. 2017; 144(1):7-34.

PMID: 29049853 PMC: 5735008. DOI: 10.1111/jnc.14242.