Guwiyang Wurra--'Fire Mouse': a Global Gene Knockout Model for TSPO/PBR Drug Development, Loss-of-function and Mechanisms of Compensation Studies

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2015 Nov 10

PMID 26551692

Citations 11

Authors

Ryan J Middleton

Guo-Jun Liu

Richard B Banati

Affiliations

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Abstract

The highly conserved 18-kDa translocator protein (TSPO) or peripheral benzodiazepine receptor (PBR), is being investigated as a diagnostic and therapeutic target for disease conditions ranging from inflammation to neurodegeneration and behavioural illnesses. Many functions have been attributed to TSPO/PBR including a role in the mitochondrial permeability transition pore (MPTP), steroidogenesis and energy metabolism. In this review, we detail the recent developments in determining the physiological role of TSPO/PBR, specifically based on data obtained from the recently generated Tspo knockout mouse models. In addition to defining the role of TSPO/PBR, we also describe the value of Tspo knockout mice in determining the selectivity, specificity and presence of any off-target effects of TSPO/PBR ligands.

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