Peroxisome Proliferator-activated Receptor Gamma (PPARG) Rs1801282 C>G Polymorphism is Associated with Cancer Susceptibility in Asians: an Updated Meta-analysis

Overview

Journal Int J Clin Exp Med

Specialty General Medicine

Date 2015 Nov 10

PMID 26550180

Citations 7

Authors

Yafeng Wang

Yu Chen

Heping Jiang

Weifeng Tang

Mingqiang Kang

Tianyun Liu

Zengqing Guo

Zhiqiang Ma

Affiliations

Soon will be listed here.

Abstract

Peroxisome proliferator-activated receptor gamma (PPARG) is related to inflammation and plays an important role in the development of cancer. PPARG rs1801282 C>G polymorphism might influence the risk of cancer by regulating production of PPARG gene. Hence, a comprehensive meta-analysis was conducted to explore the association of PPARG rs1801282 C>G polymorphism with cancer susceptibility. An extensive search of PubMed and Embase databases for all relevant publications was carried out. A total of 38 publications with 16,844 cancer cases and 23,736 controls for PPARG rs1801282 C>G polymorphism were recruited in our study. Our results indicated that PPARG rs1801282 C>G variants were associated with an increased cancer risk in Asian populations and gastric cancer. In summary, the findings suggest that PPARG rs1801282 C>G polymorphism may play a crucial role in malignant transformation and the development of cancer.

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