Does Marriage Moderate Genetic Effects on Delinquency and Violence?

Overview

Journal J Marriage Fam

Date 2015 Nov 10

PMID 26549892

Citations 8

Authors

Yi Li

Hexuan Liu

Guang Guo

Affiliations

Soon will be listed here.

Abstract

Using data from the National Longitudinal Study of Adolescent to Adult Health (N = 1,254), the authors investigated whether marriage can foster desistance from delinquency and violence by moderating genetic effects. In contrast to existing gene-environment research that typically focuses on one or a few genetic polymorphisms, they extended a recently developed mixed linear model to consider the collective influence of 580 single nucleotide polymorphisms in 64 genes related to aggression and risky behavior. The mixed linear model estimates the proportion of variance in the phenotype that is explained by the single nucleotide polymorphisms. The authors found that the proportion of variance in delinquency/violence explained was smaller among married individuals than unmarried individuals. Because selection, confounding, and heterogeneity may bias the estimate of the Gene × Marriage interaction, they conducted a series of analyses to address these issues. The findings suggest that the Gene × Marriage interaction results were not seriously affected by these issues.

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References

Nelson R, Trainor B . Neural mechanisms of aggression. Nat Rev Neurosci. 2007; 8(7):536-46. DOI: 10.1038/nrn2174. View

Craig I, Halton K . Genetics of human aggressive behaviour. Hum Genet. 2009; 126(1):101-13. DOI: 10.1007/s00439-009-0695-9. View

Pritchard J, Stephens M, Donnelly P . Inference of population structure using multilocus genotype data. Genetics. 2000; 155(2):945-59. PMC: 1461096. DOI: 10.1093/genetics/155.2.945. View

Murphy D, Fox M, Timpano K, Moya P, Ren-Patterson R, Andrews A . How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology. 2008; 55(6):932-60. PMC: 2730952. DOI: 10.1016/j.neuropharm.2008.08.034. View

Linnoila V, Virkkunen M . Aggression, suicidality, and serotonin. J Clin Psychiatry. 1992; 53 Suppl:46-51. View

Gibbs R, Weinstock G, Metzker M, Muzny D, Sodergren E, Scherer S . Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 2004; 428(6982):493-521. DOI: 10.1038/nature02426. View

Beaver K, Wright J, DeLisi M, Vaughn M . Desistance from delinquency: the marriage effect revisited and extended. Soc Sci Res. 2008; 37(3):736-52. DOI: 10.1016/j.ssresearch.2007.11.003. View

Wagner B, Li J, Liu H, Guo G . Gene-environment correlation: difficulties and a natural experiment-based strategy. Am J Public Health. 2013; 103 Suppl 1:S167-73. PMC: 3778033. DOI: 10.2105/AJPH.2013.301415. View

Simons R, Lei M, Beach S, Brody G, Philibert R, Gibbons F . Social Environmental Variation, Plasticity Genes, and Aggression: Evidence for the Differential Susceptibility Hypothesis. Am Sociol Rev. 2011; 76(6):833-912. PMC: 3244082. DOI: 10.1177/0003122411427580. View

10.

Miczek K, Fish E, De Bold J, de Almeida R . Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems. Psychopharmacology (Berl). 2002; 163(3-4):434-58. DOI: 10.1007/s00213-002-1139-6. View

11.

Conley D . The promise and challenges of incorporating genetic data into longitudinal social science surveys and research. Biodemography Soc Biol. 2010; 55(2):238-51. DOI: 10.1080/19485560903415807. View

12.

Caspi A, McClay J, Moffitt T, Mill J, Martin J, Craig I . Role of genotype in the cycle of violence in maltreated children. Science. 2002; 297(5582):851-4. DOI: 10.1126/science.1072290. View

13.

Manuck S, Flory J, Ferrell R, Mann J, Muldoon M . A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Res. 2000; 95(1):9-23. DOI: 10.1016/s0165-1781(00)00162-1. View

14.

Moffitt T . Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychol Rev. 1993; 100(4):674-701. View

15.

Waite L . Does marriage matter?. Demography. 1995; 32(4):483-507. View

16.

Shirtcliff E, Granger D, Booth A, Johnson D . Low salivary cortisol levels and externalizing behavior problems in youth. Dev Psychopathol. 2005; 17(1):167-84. DOI: 10.1017/s0954579405050091. View

17.

Coccaro E, Kavoussi R, Trestman R, Gabriel S, Cooper T, Siever L . Serotonin function in human subjects: intercorrelations among central 5-HT indices and aggressiveness. Psychiatry Res. 1998; 73(1-2):1-14. DOI: 10.1016/s0165-1781(97)00108-x. View

18.

Soyka M, Preuss U, Koller G, Zill P, Bondy B . Association of 5-HT1B receptor gene and antisocial behavior in alcoholism. J Neural Transm (Vienna). 2004; 111(1):101-9. DOI: 10.1007/s00702-003-0064-0. View

19.

Anholt R, Mackay T . Genetics of aggression. Annu Rev Genet. 2012; 46:145-64. DOI: 10.1146/annurev-genet-110711-155514. View

20.

McCarthy M, Abecasis G, Cardon L, Goldstein D, Little J, Ioannidis J . Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet. 2008; 9(5):356-69. DOI: 10.1038/nrg2344. View