The Epidemiological Survey for Atovaquone Resistant Related Gene of Babesia Gibsoni in Japan

Overview

Journal J Vet Med Sci

Specialty Veterinary Medicine

Date 2015 Nov 10

PMID 26549436

Citations 5

Authors

Aiko Iguchi

Takehisa Soma

Hiroshi Suzuki

Xuenan Xuan

Affiliations

Soon will be listed here.

Abstract

In 73 gDNA samples from Babesia gibsoni-infected dogs, the M121I variant population was measured by using allele-specific real-time PCR. Although the mechanism of atovaquone against B. gibsoni has not been clearly identified, it is reported that the mitochondria cytochrome b gene of the atovaquone-resistant B. gibsoni had a single-nucleotide substitution at nt363 (G to T), which resulted in the substitution of methionine with isoleucine (M121I). In this study, 3/73 samples showed over 5% M121I variant population. Although the M121I variant population is a low percentage, it runs the risk of spreading drug-resistant parasites. It is important to prevent the spread of drug-resistance, so we need to gather information about this at regular intervals.

Citing Articles

Analysis of Genetic Diversity of cytb gene from Babesia gibsoni Isolates from Naturally Infected Dogs in Karnataka, India.

Vijaykumar L, Chikkachowdappa P, Venkatappa M, Gowda A, Jacob S, Mani S Acta Parasitol. 2023; 69(1):375-383.

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Further epidemiological survey for atovaquone resistant related gene of Babesia gibsoni in Japan during 2015-2018.

Iguchi A, Soma T, Xuan X J Vet Med Sci. 2020; 82(11):1700-1703.

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An alternative combination therapy with metronidazole, clindamycin and doxycycline for Babesia gibsoni (Asian genotype) in dogs in Hong Kong.

Almendros A, Burchell R, Wierenga J J Vet Med Sci. 2020; 82(9):1334-1340.

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Babesia gibsoni cytochrome b mutations in canine blood samples submitted to a US veterinary diagnostic laboratory.

Birkenheuer A, Marr H, Wilson J, Breitschwerdt E, Qurollo B J Vet Intern Med. 2018; 32(6):1965-1969.

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Efficacy of Azithromycin and Compounded Atovaquone for Treatment of Babesia gibsoni in Dogs.

Kirk S, Levy J, Crawford P J Vet Intern Med. 2017; 31(4):1108-1112.

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