Insular Gray Matter Volume and Objective Quality of Life in Schizophrenia

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Nov 7

PMID 26544607

Citations 10

Authors

Teruhisa Uwatoko

Miho Yoshizumi

Jun Miyata

Shiho Ubukata

Hironobu Fujiwara

Ryosaku Kawada

Manabu Kubota

Akihiko Sasamoto

Genichi Sugihara

Toshihiko Aso

Shinichi Urayama

Hidenao Fukuyama

Toshiya Murai

Hidehiko Takahashi

Affiliations

Soon will be listed here.

Abstract

Improving quality of life has been recognized as an important outcome for schizophrenia treatment, although the fundamental determinants are not well understood. In this study, we investigated the association between brain structural abnormalities and objective quality of life in schizophrenia patients. Thirty-three schizophrenia patients and 42 age-, sex-, and education-matched healthy participants underwent magnetic resonance imaging. The Quality of Life Scale was used to measure objective quality of life in schizophrenia patients. Voxel-based morphometry was performed to identify regional brain alterations that correlate with Quality of Life Scale score in the patient group. Schizophrenia patients showed gray matter reductions in the frontal, temporal, limbic, and subcortical regions. We then performed voxel-based multiple regression analysis in these regions to identify any correlations between regional gray matter volume and Quality of Life Scale scores. We found that among four subcategories of the scale, the Instrumental Role category score correlated with gray matter volume in the right anterior insula in schizophrenia patients. In addition, this correlation was shown to be mediated by negative symptoms. Our findings suggest that the neural basis of objective quality of life might differ topographically from that of subjective QOL in schizophrenia.

Citing Articles

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