The Role of Chitin, Chitinases, and Chitinase-like Proteins in Pediatric Lung Diseases

Overview

Journal Mol Cell Pediatr

Publisher Springer

Specialty Pediatrics

Date 2015 Nov 7

PMID 26542293

Citations 24

Authors

Ines Mack

Andreas Hector

Marlene Ballbach

Julius Kohlhaufl

Katharina J Fuchs

Alexander Weber

Marcus A Mall

Dominik Hartl

Affiliations

Soon will be listed here.

Abstract

Chitin, after cellulose, the second most abundant biopolymer on earth, is a key component of insects, fungi, and house-dust mites. Lower life forms are endowed with chitinases to defend themselves against chitin-bearing pathogens. Unexpectedly, humans were also found to express chitinases as well as chitinase-like proteins that modulate immune responses. Particularly, increased levels of the chitinase-like protein YKL-40 have been associated with severe asthma, cystic fibrosis, and other inflammatory disease conditions. Here, we summarize and discuss the potential role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases.

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