Mini-review: Emerging Roles of MicroRNAs in the Pathophysiology of Renal Diseases

Overview

Journal Am J Physiol Renal Physiol

Publisher American Physiological Society

Specialties Nephrology
Physiology

Date 2015 Nov 6

PMID 26538441

Citations 44

Authors

Kirti Bhatt

Mitsuo Kato

Rama Natarajan

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNA) are endogenously produced short noncoding regulatory RNAs that can repress gene expression by posttranscriptional mechanisms. They can therefore influence both normal and pathological conditions in diverse biological systems. Several miRNAs have been detected in kidneys, where they have been found to be crucial for renal development and normal physiological functions as well as significant contributors to the pathogenesis of renal disorders such as diabetic nephropathy, acute kidney injury, lupus nephritis, polycystic kidney disease, and others, due to their effects on key genes involved in these disease processes. miRNAs have also emerged as novel biomarkers in these renal disorders. Due to increasing evidence of their actions in various kidney segments, in this mini-review we discuss the functional significance of altered miRNA expression during the development of renal pathologies and highlight emerging miRNA-based therapeutics and diagnostic strategies for early detection and treatment of kidney diseases.

Citing Articles

Downregulation of hsa-miR-100-5p May Be a Protective Factor in the Early Stages of Nephropathy in Type 1 Diabetes Mellitus.

Pinheiro A, de Oliveira Pereira B, Silva L, Melo F, Souza A, Leal V Int J Mol Sci. 2024; 25(11).

PMID: 38891851 PMC: 11171847. DOI: 10.3390/ijms25115663.

Extracellular vesicles in chronic kidney disease: diagnostic and therapeutic roles.

Zheng Y, Wang H, Li X, Xie J, Fan J, Ren S Front Pharmacol. 2024; 15:1371874.

PMID: 38545551 PMC: 10965796. DOI: 10.3389/fphar.2024.1371874.

Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action.

Wan X, Liao J, Lai H, Zhang S, Cui J, Chen C Front Endocrinol (Lausanne). 2023; 14:1179161.

PMID: 37396169 PMC: 10309560. DOI: 10.3389/fendo.2023.1179161.

Bone marrow mesenchymal stem cell-derived exosomal miR-30e-5p ameliorates high-glucose induced renal proximal tubular cell pyroptosis by inhibiting ELAVL1.

Lv J, Hao Y, Wang X, Lu W, Xie L, Niu D Ren Fail. 2023; 45(1):2177082.

PMID: 36794663 PMC: 9937013. DOI: 10.1080/0886022X.2023.2177082.

Analysis of exosome-derived microRNAs as early biomarkers of lipopolysaccharide-induced acute kidney injury in rats.

Da-Silva C, Anauate A, Guirao T, da Silva Novaes A, Maquigussa E, Boim M Front Physiol. 2022; 13:944864.

PMID: 36091362 PMC: 9462429. DOI: 10.3389/fphys.2022.944864.

References

Wilflingseder J, Sunzenauer J, Toronyi E, Heinzel A, Kainz A, Mayer B . Molecular pathogenesis of post-transplant acute kidney injury: assessment of whole-genome mRNA and miRNA profiles. PLoS One. 2014; 9(8):e104164. PMC: 4122455. DOI: 10.1371/journal.pone.0104164. View

Babelova A, Avaniadi D, Jung O, Fork C, Beckmann J, Kosowski J . Role of Nox4 in murine models of kidney disease. Free Radic Biol Med. 2012; 53(4):842-53. DOI: 10.1016/j.freeradbiomed.2012.06.027. View

Mendell J, Olson E . MicroRNAs in stress signaling and human disease. Cell. 2012; 148(6):1172-87. PMC: 3308137. DOI: 10.1016/j.cell.2012.02.005. View

Bijkerk R, van Solingen C, de Boer H, van der Pol P, Khairoun M, de Bruin R . Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity. J Am Soc Nephrol. 2014; 25(8):1710-22. PMC: 4116053. DOI: 10.1681/ASN.2013060640. View

Barutta F, Tricarico M, Corbelli A, Annaratone L, Pinach S, Grimaldi S . Urinary exosomal microRNAs in incipient diabetic nephropathy. PLoS One. 2013; 8(11):e73798. PMC: 3817183. DOI: 10.1371/journal.pone.0073798. View

Lai J, Luo J, OConnor C, Jing X, Nair V, Ju W . MicroRNA-21 in glomerular injury. J Am Soc Nephrol. 2014; 26(4):805-16. PMC: 4378097. DOI: 10.1681/ASN.2013121274. View

Lee S, Masyuk T, Splinter P, Banales J, Masyuk A, Stroope A . MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. J Clin Invest. 2008; 118(11):3714-24. PMC: 2571032. DOI: 10.1172/JCI34922. View

Lu J, Kwan B, Lai F, Tam L, Li E, Chow K . Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis. Nephrology (Carlton). 2012; 17(4):346-51. DOI: 10.1111/j.1440-1797.2012.01573.x. View

Wang E, Hsieh-Li H, Chiou Y, Chien Y, Ho H, Chin H . Progressive renal distortion by multiple cysts in transgenic mice expressing artificial microRNAs against Pkd1. J Pathol. 2010; 222(3):238-48. DOI: 10.1002/path.2765. View

10.

Trionfini P, Benigni A, Remuzzi G . MicroRNAs in kidney physiology and disease. Nat Rev Nephrol. 2014; 11(1):23-33. DOI: 10.1038/nrneph.2014.202. View

11.

Wang B, Herman-Edelstein M, Koh P, Burns W, Jandeleit-Dahm K, Watson A . E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-beta. Diabetes. 2010; 59(7):1794-802. PMC: 2889781. DOI: 10.2337/db09-1736. View

12.

Ruggenenti P, Cravedi P, Remuzzi G . The RAAS in the pathogenesis and treatment of diabetic nephropathy. Nat Rev Nephrol. 2010; 6(6):319-30. DOI: 10.1038/nrneph.2010.58. View

13.

Fabbri M . miRNAs as molecular biomarkers of cancer. Expert Rev Mol Diagn. 2010; 10(4):435-44. DOI: 10.1586/erm.10.27. View

14.

Johnson S, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A . RAS is regulated by the let-7 microRNA family. Cell. 2005; 120(5):635-47. DOI: 10.1016/j.cell.2005.01.014. View

15.

Julian B, Wittke S, Haubitz M, Zurbig P, Schiffer E, McGuire B . Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases. World J Urol. 2007; 25(5):467-76. DOI: 10.1007/s00345-007-0192-5. View

16.

Du B, Ma L, Huang M, Zhou H, Huang H, Shao P . High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells. FEBS Lett. 2010; 584(4):811-6. DOI: 10.1016/j.febslet.2009.12.053. View

17.

Szeto C, Li P . MicroRNAs in IgA nephropathy. Nat Rev Nephrol. 2014; 10(5):249-56. DOI: 10.1038/nrneph.2014.50. View

18.

Wang B, Jha J, Hagiwara S, McClelland A, Jandeleit-Dahm K, Thomas M . Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b. Kidney Int. 2013; 85(2):352-61. DOI: 10.1038/ki.2013.372. View

19.

Lorenzen J, Kielstein J, Hafer C, Gupta S, Kumpers P, Faulhaber-Walter R . Circulating miR-210 predicts survival in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol. 2011; 6(7):1540-6. DOI: 10.2215/CJN.00430111. View

20.

Brennan E, Nolan K, Borgeson E, Gough O, McEvoy C, Docherty N . Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1. J Am Soc Nephrol. 2013; 24(4):627-37. PMC: 3609134. DOI: 10.1681/ASN.2012060550. View