Bovine Serum Albumin Interactions with Metal Complexes

Overview

Journal Clujul Med

Specialty General Medicine

Date 2015 Nov 4

PMID 26528027

Citations 44

Authors

Tamara Topala

Andreea Bodoki

Luminita Oprean

Radu Oprean

Affiliations

Soon will be listed here.

Abstract

The continuous search for new molecules with therapeutic abilities has led to the synthesis and characterization of a large number of metal complexes, proven to exhibit potential as pharmacological agents through their antibacterial, antiviral, antifungal and antineoplastic properties. As serum albumins play a key role in drug pharmacokinetics and pharmacodynamics, the study of coordination compounds affinity towards this class of proteins, as well as understanding the mechanism through which they interact is crucial. The aim of this review is to focus on the structure and biological functions of bovine serum albumin, the design of metal complexes that are able to bind to the biomolecule, as well as the experimental techniques employed in the study and evaluation of these interactions.

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