Controlling the Connections of Cells to the Biofilm Matrix

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2015 Nov 4

PMID 26527642

Citations 8

Authors

Matthew R Parsek

Affiliations

Soon will be listed here.

Abstract

The importance of cyclic di-GMP (c-di-GMP) and its control of biofilm matrix assembly and production has been a focal point of researchers in recent history. In this issue, Cooley et al. (Cooley RB, Smith TJ, Leung W, Tierney V, Borlee BR, O'Toole GA, Sondermann H, J Bacteriol 198:66-77, http://dx.doi.org/10.1128/JB.00369-15) demonstrate that two c-di-GMP controlled features of Pseudomonas aeruginosa, the periplasmic protease LapG and the surface adhesin CdrA, are linked. CdrA is shown to be a substrate of LapG, with LapG activity controlled by intracellular c-di-GMP levels. This commentary discusses the significance of this finding.

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References

Costerton J, Stewart P . Battling biofilms. Sci Am. 2001; 285(1):74-81. DOI: 10.1038/scientificamerican0701-74. View

Cooley R, Smith T, Leung W, Tierney V, Borlee B, OToole G . Cyclic Di-GMP-Regulated Periplasmic Proteolysis of a Pseudomonas aeruginosa Type Vb Secretion System Substrate. J Bacteriol. 2015; 198(1):66-76. PMC: 4686201. DOI: 10.1128/JB.00369-15. View

Hall-Stoodley L, Costerton J, Stoodley P . Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol. 2004; 2(2):95-108. DOI: 10.1038/nrmicro821. View

Branda S, Vik S, Friedman L, Kolter R . Biofilms: the matrix revisited. Trends Microbiol. 2005; 13(1):20-6. DOI: 10.1016/j.tim.2004.11.006. View

Hickman J, Tifrea D, Harwood C . A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels. Proc Natl Acad Sci U S A. 2005; 102(40):14422-7. PMC: 1234902. DOI: 10.1073/pnas.0507170102. View

Hinsa S, OToole G . Biofilm formation by Pseudomonas fluorescens WCS365: a role for LapD. Microbiology (Reading). 2006; 152(Pt 5):1375-1383. DOI: 10.1099/mic.0.28696-0. View

Newell P, Monds R, OToole G . LapD is a bis-(3',5')-cyclic dimeric GMP-binding protein that regulates surface attachment by Pseudomonas fluorescens Pf0-1. Proc Natl Acad Sci U S A. 2009; 106(9):3461-6. PMC: 2651287. DOI: 10.1073/pnas.0808933106. View

Ma L, Conover M, Lu H, Parsek M, Bayles K, Wozniak D . Assembly and development of the Pseudomonas aeruginosa biofilm matrix. PLoS Pathog. 2009; 5(3):e1000354. PMC: 2654510. DOI: 10.1371/journal.ppat.1000354. View

Starkey M, Hickman J, Ma L, Zhang N, De Long S, Hinz A . Pseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lung. J Bacteriol. 2009; 191(11):3492-503. PMC: 2681918. DOI: 10.1128/JB.00119-09. View

10.

Ueda A, Wood T . Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885). PLoS Pathog. 2009; 5(6):e1000483. PMC: 2691606. DOI: 10.1371/journal.ppat.1000483. View

11.

Schirmer T, Jenal U . Structural and mechanistic determinants of c-di-GMP signalling. Nat Rev Microbiol. 2009; 7(10):724-35. DOI: 10.1038/nrmicro2203. View

12.

Gjermansen M, Nilsson M, Yang L, Tolker-Nielsen T . Characterization of starvation-induced dispersion in Pseudomonas putida biofilms: genetic elements and molecular mechanisms. Mol Microbiol. 2009; 75(4):815-26. DOI: 10.1111/j.1365-2958.2009.06793.x. View

13.

Borlee B, Goldman A, Murakami K, Samudrala R, Wozniak D, Parsek M . Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix. Mol Microbiol. 2010; 75(4):827-42. PMC: 2847200. DOI: 10.1111/j.1365-2958.2009.06991.x. View

14.

Newell P, Boyd C, Sondermann H, OToole G . A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage. PLoS Biol. 2011; 9(2):e1000587. PMC: 3032545. DOI: 10.1371/journal.pbio.1000587. View

15.

Navarro M, Newell P, Krasteva P, Chatterjee D, Madden D, OToole G . Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. PLoS Biol. 2011; 9(2):e1000588. PMC: 3032553. DOI: 10.1371/journal.pbio.1000588. View

16.

Berk V, Fong J, Dempsey G, Develioglu O, Zhuang X, Liphardt J . Molecular architecture and assembly principles of Vibrio cholerae biofilms. Science. 2012; 337(6091):236-9. PMC: 3513368. DOI: 10.1126/science.1222981. View

17.

Romling U . Cyclic di-GMP, an established secondary messenger still speeding up. Environ Microbiol. 2011; 14(8):1817-29. DOI: 10.1111/j.1462-2920.2011.02617.x. View

18.

Boyd C, Chatterjee D, Sondermann H, OToole G . LapG, required for modulating biofilm formation by Pseudomonas fluorescens Pf0-1, is a calcium-dependent protease. J Bacteriol. 2012; 194(16):4406-14. PMC: 3416268. DOI: 10.1128/JB.00642-12. View

19.

Romling U, Galperin M, Gomelsky M . Cyclic di-GMP: the first 25 years of a universal bacterial second messenger. Microbiol Mol Biol Rev. 2013; 77(1):1-52. PMC: 3591986. DOI: 10.1128/MMBR.00043-12. View

20.

Chatterjee D, Cooley R, Boyd C, Mehl R, OToole G, Sondermann H . Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP. Elife. 2014; 3:e03650. PMC: 4359373. DOI: 10.7554/eLife.03650. View