Sugar Activation and Glycosylation in Plasmodium

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2015 Nov 2

PMID 26520586

Citations 28

Authors

Marta Cova

Joao A Rodrigues

Terry K Smith

Luis Izquierdo

Affiliations

Soon will be listed here.

Abstract

Glycoconjugates are important mediators of host-pathogen interactions and are usually very abundant in the surface of many protozoan parasites. However, in the particular case of Plasmodium species, previous works show that glycosylphosphatidylinositol anchor modifications, and to an unknown extent, a severely truncated N-glycosylation are the only glycosylation processes taking place in the parasite. Nevertheless, a detailed analysis of the parasite genome and the recent identification of the sugar nucleotide precursors biosynthesized by Plasmodium falciparum support a picture in which several overlooked, albeit not very prominent glycosylations may be occurring during the parasite life cycle. In this work, the authors review recent developments in the characterization of the biosynthesis of glycosylation precursors in the parasite, focusing on the outline of the possible fates of these precursors.

Citing Articles

Glycosylation in malaria parasites: what do we know?.

Gowda D, Miller L Trends Parasitol. 2024; 40(2):131-146.

PMID: 38262838 PMC: 10923157. DOI: 10.1016/j.pt.2023.12.006.

Aptamer-Based Imaging of Polyisoprenoids in the Malaria Parasite.

Zimbres F, Merino E, Butschek G, Butler J, Duconge F, Cassera M Molecules. 2024; 29(1).

PMID: 38202761 PMC: 10780415. DOI: 10.3390/molecules29010178.

MSP1-42 kD Variant Proteins Detected Naturally Induced IgG Antibodies in Patients Regardless of the Infecting Parasite Phenotype in Mesoamerica.

Gonzalez-Ceron L, Dema B, Palomeque-Culebro O, Santillan-Valenzuela F, Montoya A, Reyes-Sandoval A Life (Basel). 2023; 13(3).

PMID: 36983859 PMC: 10058798. DOI: 10.3390/life13030704.

Exploring expression and immune potency in mice using mRNA encoding the malaria antigen, CelTOS.

Waghela I, Mallory K, Taylor J, Schneider C, Savransky T, Janse C Front Immunol. 2023; 13:1026052.

PMID: 36591298 PMC: 9798330. DOI: 10.3389/fimmu.2022.1026052.

Isoprenoid alcohols utilization by malaria parasites.

Verdaguer I, Sussmann R, Feijoli Santiago V, Palmisano G, Moura G, Mesquita J Front Chem. 2022; 10:1035548.

PMID: 36531309 PMC: 9751614. DOI: 10.3389/fchem.2022.1035548.

References

Clark I, Cowden W . The pathophysiology of falciparum malaria. Pharmacol Ther. 2003; 99(2):221-60. DOI: 10.1016/s0163-7258(03)00060-3. View

Watanabe R, Inoue N, Westfall B, Taron C, Orlean P, Takeda J . The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. EMBO J. 1998; 17(4):877-85. PMC: 1170437. DOI: 10.1093/emboj/17.4.877. View

Buettner F, Ashikov A, Tiemann B, Lehle L, Bakker H . C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats. Mol Cell. 2013; 50(2):295-302. DOI: 10.1016/j.molcel.2013.03.003. View

Samuelson J, Banerjee S, Magnelli P, Cui J, Kelleher D, Gilmore R . The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases. Proc Natl Acad Sci U S A. 2005; 102(5):1548-53. PMC: 545090. DOI: 10.1073/pnas.0409460102. View

Kimura E, Couto A, Peres V, Casal O, Katzin A . N-linked glycoproteins are related to schizogony of the intraerythrocytic stage in Plasmodium falciparum. J Biol Chem. 1996; 271(24):14452-61. DOI: 10.1074/jbc.271.24.14452. View

Ferguson M . The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research. J Cell Sci. 1999; 112 ( Pt 17):2799-809. DOI: 10.1242/jcs.112.17.2799. View

Ravindran B, Satapathy A, Das M . Naturally-occurring anti-alpha-galactosyl antibodies in human Plasmodium falciparum infections--a possible role for autoantibodies in malaria. Immunol Lett. 1988; 19(2):137-41. DOI: 10.1016/0165-2478(88)90133-2. View

Shams-Eldin H, Santos de Macedo C, Niehus S, Dorn C, Kimmel J, Azzouz N . Plasmodium falciparum dolichol phosphate mannose synthase represents a novel clade. Biochem Biophys Res Commun. 2008; 370(3):388-93. DOI: 10.1016/j.bbrc.2008.03.033. View

Hong Y, Ohishi K, Watanabe R, Endo Y, Maeda Y, Kinoshita T . GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis. J Biol Chem. 1999; 274(26):18582-8. DOI: 10.1074/jbc.274.26.18582. View

10.

Sultan A, Thathy V, Frevert U, Robson K, Crisanti A, NUSSENZWEIG V . TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites. Cell. 1997; 90(3):511-22. DOI: 10.1016/s0092-8674(00)80511-5. View

11.

von Itzstein M, Plebanski M, Cooke B, Coppel R . Hot, sweet and sticky: the glycobiology of Plasmodium falciparum. Trends Parasitol. 2008; 24(5):210-8. DOI: 10.1016/j.pt.2008.02.007. View

12.

Trombetta E, Parodi A . Quality control and protein folding in the secretory pathway. Annu Rev Cell Dev Biol. 2003; 19:649-76. DOI: 10.1146/annurev.cellbio.19.110701.153949. View

13.

Botte C, Yamaryo-Botte Y, Rupasinghe T, Mullin K, MacRae J, Spurck T . Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites. Proc Natl Acad Sci U S A. 2013; 110(18):7506-11. PMC: 3645554. DOI: 10.1073/pnas.1301251110. View

14.

Tucker R . The thrombospondin type 1 repeat superfamily. Int J Biochem Cell Biol. 2004; 36(6):969-74. DOI: 10.1016/j.biocel.2003.12.011. View

15.

Agnandji S, Lell B, Soulanoudjingar S, Fernandes J, Abossolo B, Conzelmann C . First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med. 2011; 365(20):1863-75. DOI: 10.1056/NEJMoa1102287. View

16.

Sanz S, Bandini G, Ospina D, Bernabeu M, Marino K, Fernandez-Becerra C . Biosynthesis of GDP-fucose and other sugar nucleotides in the blood stages of Plasmodium falciparum. J Biol Chem. 2013; 288(23):16506-16517. PMC: 3675586. DOI: 10.1074/jbc.M112.439828. View

17.

Helenius A, Aebi M . Roles of N-linked glycans in the endoplasmic reticulum. Annu Rev Biochem. 2004; 73:1019-49. DOI: 10.1146/annurev.biochem.73.011303.073752. View

18.

Olszewski K, Llinas M . Central carbon metabolism of Plasmodium parasites. Mol Biochem Parasitol. 2010; 175(2):95-103. PMC: 3004993. DOI: 10.1016/j.molbiopara.2010.09.001. View

19.

Arrighi R, Faye I . Plasmodium falciparum GPI toxin: a common foe for man and mosquito. Acta Trop. 2009; 114(3):162-5. DOI: 10.1016/j.actatropica.2009.06.003. View

20.

Moremen K, Molinari M . N-linked glycan recognition and processing: the molecular basis of endoplasmic reticulum quality control. Curr Opin Struct Biol. 2006; 16(5):592-9. PMC: 3976202. DOI: 10.1016/j.sbi.2006.08.005. View