Progression After AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments

Overview

Journal J Am Soc Nephrol

Specialty Nephrology

Date 2015 Nov 1

PMID 26519085

Citations 220

Authors

David P Basile

Joseph V Bonventre

Ravindra Mehta

Masaomi Nangaku

Robert Unwin

Mitchell H Rosner

John A Kellum

Claudio Ronco

Affiliations

Soon will be listed here.

Abstract

Recent clinical studies indicate a strong link between AKI and progression of CKD. The increasing prevalence of AKI must compel the nephrology community to consider the long-term ramifications of this syndrome. Considerable gaps in knowledge exist regarding the connection between AKI and CKD. The 13th Acute Dialysis Quality Initiative meeting entitled "Therapeutic Targets of Human Acute Kidney Injury: Harmonizing Human and Experimental Animal Acute Kidney Injury" convened in April of 2014 and assigned a working group to focus on issues related to progression after AKI. This article provides a summary of the key conclusions and recommendations of the group, including an emphasis on terminology related to injury and repair processes for both clinical and preclinical studies, elucidation of pathophysiologic alterations of AKI, identification of potential treatment strategies, identification of patients predisposed to progression, and potential management strategies.

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