Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol

Overview

Journal Med Sci Monit

Specialties General Medicine
Pathology

Date 2015 Oct 31

PMID 26517086

Citations 12

Authors

Jian-Chun Li

Na Zhu

Jin-Xiu Zhu

Wen-Jing Zhang

Hong-Min Zhang

Qing-Qing Wang

Xiao-Xiang Wu

Xiu Wang

Jin Zhang

Ji-Fu Hao

Affiliations

Soon will be listed here.

Abstract

Background: The aim of this study was to optimize the preparation method for self-assembled glyceryl monoolein-based cubosomes containing paeonol and to characterize the properties of this transdermal delivery system to improve the drug penetration ability in the skin.

Material And Methods: In this study, the cubic liquid crystalline nanoparticles loaded with paeonol were prepared by fragmentation of glyceryl monoolein (GMO)/poloxamer 407 bulk cubic gel by high-pressure homogenization. We evaluated the Zeta potential of these promising skin-targeting drug-delivery systems using the Malvern Zeta sizer examination, and various microscopies and differential scanning calorimetry were also used for property investigation. Stimulating studies were evaluated based on the skin irritation reaction score standard and the skin stimulus intensity evaluation standard for paeonol cubosomes when compared with commercial paeonol ointment. In vitro tests were performed on excised rat skins in an improved Franz diffusion apparatus. The amount of paeonol over time in the in vitro penetration and retention experiments both was determined quantitatively by HPLC.

Results: Stimulating studies were compared with the commercial ointment which indicated that the paeonol cubic liquid crystalline nanoparticles could reduce the irritation in the skin stimulating test. Thus, based on the attractive characteristics of the cubic crystal system of paeonol, we will further exploit the cosmetic features in the future studies.

Conclusions: The transdermal delivery system of paeonol with low-irritation based on the self-assembled cubic liquid crystalline nanoparticles prepared in this study might be a promising system of good tropical preparation for skin application.

Citing Articles

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Mahmoud T, Abdelfatah M, Omar M, Hasan O, Wali S, El-Mofty M Pharmaceutics. 2025; 17(1).

PMID: 39861720 PMC: 11769262. DOI: 10.3390/pharmaceutics17010072.

Investigation of paeonol in dermatological diseases: an animal study review.

Ju J, Song T, Shi J, Li J Front Pharmacol. 2024; 15:1450816.

PMID: 39588155 PMC: 11586225. DOI: 10.3389/fphar.2024.1450816.

Factors affecting the structure of lyotropic liquid crystals and the correlation between structure and drug diffusion.

Huang Y, Gui S RSC Adv. 2022; 8(13):6978-6987.

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Formation of Self-Assembled Liquid Crystalline Nanoparticles and Absorption Enhancement of Ω-3s by Phospholipids and Oleic Acids.

Jeon S, Jin H, Park Y Pharmaceutics. 2022; 14(1).

PMID: 35056964 PMC: 8781607. DOI: 10.3390/pharmaceutics14010068.

Biological Activities of Paeonol in Cardiovascular Diseases: A Review.

Vellasamy S, Murugan D, Abas R, Alias A, Seng W, Woon C Molecules. 2021; 26(16).

PMID: 34443563 PMC: 8400614. DOI: 10.3390/molecules26164976.

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