Mechanisms of Long-term Cognitive Dysfunction of Sepsis: from Blood-borne Leukocytes to Glial Cells

Overview

Journal Intensive Care Med Exp

Specialty Critical Care

Date 2015 Oct 31

PMID 26515197

Citations 25

Authors

Monique Michels

Amanda V Steckert

Joao Quevedo

Tatiana Barichello

Felipe Dal-Pizzol

Affiliations

Soon will be listed here.

Abstract

Several mechanisms are associated with brain dysfunction during sepsis; one of the most important are activation of microglia and astrocytes. Activation of glial cells induces changes in permeability of the blood-brain barrier, secretion of inflammatory cytokines, and these alterations could induce neuronal dysfunction. Furthermore, blood-borne leukocytes can also reach the brain and participate in inflammatory response. Mechanisms involved in sepsis-associated brain dysfunction were revised here, focusing in neuroinflammation and involvement of blood-borne leukocytes and glial cells in this process.

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