Effect of Summer Daylight Exposure and Genetic Background on Growth in Growth Hormone-deficient Children

Overview

Journal Pharmacogenomics J

Specialties Genetics
Molecular Biology
Pharmacology

Date 2015 Oct 28

PMID 26503811

Citations 11

Authors

C De Leonibus

P Chatelain

C Knight

P Clayton

A Stevens

Affiliations

Soon will be listed here.

Abstract

The response to growth hormone in humans is dependent on phenotypic, genetic and environmental factors. The present study in children with growth hormone deficiency (GHD) collected worldwide characterised gene-environment interactions on growth response to recombinant human growth hormone (r-hGH). Growth responses in children are linked to latitude, and we found that a correlate of latitude, summer daylight exposure (SDE), was a key environmental factor related to growth response to r-hGH. In turn growth response was determined by an interaction between both SDE and genes known to affect growth response to r-hGH. In addition, analysis of associated networks of gene expression implicated a role for circadian clock pathways and specifically the developmental transcription factor NANOG. This work provides the first observation of gene-environment interactions in children treated with r-hGH.

Citing Articles

Gene Expression Signatures Predict First-Year Response to Somapacitan Treatment in Children With Growth Hormone Deficiency.

Garner T, Clayton P, Hojby M, Murray P, Stevens A J Clin Endocrinol Metab. 2023; 109(5):1214-1221.

PMID: 38066644 PMC: 11031233. DOI: 10.1210/clinem/dgad717.

Seasonality of Children's Height and Weight and Their Contribution to Accelerated Summer Weight Gain.

Moreno J, Musaad S, Dadabhoy H, Baranowski T, Crowley S, Thompson D Front Physiol. 2022; 13:793999.

PMID: 35665226 PMC: 9159375. DOI: 10.3389/fphys.2022.793999.

Gene expression signatures predict response to therapy with growth hormone.

Stevens A, Murray P, De Leonibus C, Garner T, Koledova E, Ambler G Pharmacogenomics J. 2021; 21(5):594-607.

PMID: 34045667 PMC: 8455334. DOI: 10.1038/s41397-021-00237-5.

Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature.

Stevens A, Perchard R, Garner T, Clayton P, Murray P Rev Endocr Metab Disord. 2021; 22(1):135-143.

PMID: 33712998 PMC: 7979669. DOI: 10.1007/s11154-021-09637-1.

Regional Differences in Height, Weight, and Body Composition may Result from Photoperiodic Responses: An Ecological Analysis of Japanese Children and Adolescents.

Yokoya M, Terada A J Circadian Rhythms. 2021; 19:3.

PMID: 33664773 PMC: 7908924. DOI: 10.5334/jcr.198.

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