Antibiotic Prophylaxis for Shunt Surgery of Children: a Systematic Review

Overview

Journal Childs Nerv Syst

Specialty Pediatrics

Date 2015 Oct 27

PMID 26499129

Citations 6

Authors

H Xu

F Hu

H Hu

W Sun

W Jiao

R Li

T Lei

Affiliations

Soon will be listed here.

Abstract

Objective: The object of this study was to evaluate the clinical effectiveness of antibiotic prophylaxis in children who underwent placement of intracranial ventricular shunts.

Methods: In this paper, the authors report a systematic review and meta-analysis of infection rate for pediatric shunt implantation surgery. Randomized or non-randomized controlled trials for comparing the use of prophylactic antibiotics in intracranial ventricular shunt procedures with placebo or no antibiotics were included in the review.

Results: Seven published reports of eligible studies involving 694 participants meet the inclusion criteria. Compared with the control group, antibiotic prophylaxis had made a significant difference in infection rate (RR = 0.59, 95% CI = 0.38, 0.90, P < 0.05).

Conclusion: Although current evidence demonstrates that antibiotic prophylaxis can lead to a significant reduction of the infection rate of shunt surgery, more evidence from advanced multi-center studies is needed to provide instruction for the use of prophylactic antibiotics.

Citing Articles

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Sahin Y, Sayin E, Aslan Y, Bayri Y Childs Nerv Syst. 2024; 40(6):1765-1769.

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Licona-Enriquez J, Labra-Zamora M, Ramirez-Reyes A, Miranda-Novales M Antibiotics (Basel). 2023; 12(10).

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Surgical Antimicrobial Prophylaxis in Neonates and Children Undergoing Neurosurgery: A RAND/UCLA Appropriateness Method Consensus Study.

Esposito S, Zucchelli M, Bianchini S, Nicoletti L, Monaco S, Rigotti E Antibiotics (Basel). 2022; 11(7).

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Prophylactic antibiotics in pediatric neurological surgery.

Knerlich-Lukoschus F, Messing-Junger M Childs Nerv Syst. 2018; 34(10):1859-1864.

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Topical vancomycin reduces the cerebrospinal fluid shunt infection rate: A retrospective cohort study.

van Lindert E, van Bilsen M, van der Flier M, Kolwijck E, Delye H, Ten Oever J PLoS One. 2018; 13(1):e0190249.

PMID: 29315341 PMC: 5760031. DOI: 10.1371/journal.pone.0190249.

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