Nasal Mucociliary Clearance in Adenoid Hypertrophy and Otitis Media with Effusion

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2015 Oct 27

PMID 26496764

Citations 7

Authors

Hasmet Yazici

Affiliations

Soon will be listed here.

Abstract

Mucociliary clearance (MCC), which exists in many systems, is the first defensive mechanism of the human body. Nasal MCC has an important role in transporting the secretions of the nasal cavity and paranasal sinuses along with the trapped inhaled pathogens to the nasopharynx. Physiologic or pathologic situations that effect nasal MCC, such as temperature, humidity, nasal obstruction, allergic rhinitis, chronic infections, etc., lead to impaired MCC and related local or circumjacent system disorders. With this perspective, when a unified airway with a multiple disease principle is considered, investigating the relationship between adenoid hypertrophy (AH), otitis media with effusion (OME) and nasal MCC is logical. In this review, histological and physiologic properties of nasal MCC and its possible role involving pathologic situations such as AH and OME is discussed together with recent literature findings.

Citing Articles

Adenoid facies: a long-term vicious cycle of mouth breathing, adenoid hypertrophy, and atypical craniofacial development.

Zhang J, Fu Y, Wang L, Wu G Front Public Health. 2024; 12:1494517.

PMID: 39726660 PMC: 11669592. DOI: 10.3389/fpubh.2024.1494517.

The therapeutic use of exosomes in children with adenoid hypertrophy accompanied by otitis media with effusion (AHOME): a protocol study.

Liu Y, Lu X, Sun S, Yu H, Li H BMC Pediatr. 2024; 24(1):521.

PMID: 39134977 PMC: 11318249. DOI: 10.1186/s12887-024-04999-2.

Otitis media with effusion in preschool children with adenoid hypertrophy: Risk factors and nursing care.

Hu R, Xia L, Shi C, Zhou Y, Guo X Nurs Open. 2024; 11(5):e2165.

PMID: 38701327 PMC: 11068218. DOI: 10.1002/nop2.2165.

Allergy in pathogenesis of Eustachian Tube Dysfunction.

Yu X, Zhang H, Zong S, Xiao H World Allergy Organ J. 2024; 17(1):100860.

PMID: 38274710 PMC: 10809091. DOI: 10.1016/j.waojou.2023.100860.

Proteomic Study of Middle Ear Effusion and Its Clinical Application for Otitis Media with Effusion.

Wang X, Xu J, Feng G, Gao Z, Sun W Infect Drug Resist. 2023; 16:5923-5940.

PMID: 37700801 PMC: 10494926. DOI: 10.2147/IDR.S424475.

References

Shaari J, Palmer J, Chiu A, Judy K, Cohen A, Kennedy D . Regional analysis of sinonasal ciliary beat frequency. Am J Rhinol. 2006; 20(2):150-4. View

Cingi C, Altin F, Cakli H, Entok E, Gurbuz K, Cingi E . Scintigraphic evaluation of nasal mucociliary activity in unilateral chronic otitis media. J Laryngol Otol. 2005; 119(6):443-7. DOI: 10.1258/0022215054273098. View

Gonzalez C, Espinosa M, Sanchez M, Droguett K, Rios M, Fonseca X . Epithelial cell culture from human adenoids: a functional study model for ciliated and secretory cells. Biomed Res Int. 2013; 2013:478713. PMC: 3581098. DOI: 10.1155/2013/478713. View

Kawabata I, Paparella M . Ultrastructure of normal human middle ear mucosa. Preliminary report. Ann Otol Rhinol Laryngol. 1969; 78(1):125-37. DOI: 10.1177/000348946907800111. View

Marple B . Allergic rhinitis and inflammatory airway disease: interactions within the unified airspace. Am J Rhinol Allergy. 2010; 24(4):249-54. DOI: 10.2500/ajra.2010.24.3499. View

Ranga R, Singh J, Gera A, Yadav J . Nasal mucociliary clearance in adenotonsillar hypertrophy. Indian J Pediatr. 2000; 67(9):651-2. DOI: 10.1007/BF02762176. View

Chen B, Antunes M, Eau Claire S, Palmer J, Chiu A, Kennedy D . Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction. Am J Rhinol. 2007; 21(3):346-53. DOI: 10.2500/ajr.2007.21.3029. View

Kerschner J, Hong W, Khampang P, Johnston N . Differential response of gel-forming mucins to pathogenic middle ear bacteria. Int J Pediatr Otorhinolaryngol. 2014; 78(8):1368-73. PMC: 4104932. DOI: 10.1016/j.ijporl.2014.05.037. View

Elsheikh M, Mahfouz M . Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion. Laryngoscope. 2006; 116(3):365-9. DOI: 10.1097/01.MLG.0000195290.71090.A1. View

10.

Sade J . Ciliary activity and middle ear clearance. Arch Otolaryngol. 1967; 86(2):128-35. View

11.

Karja J, Nuutinen J, Karjalainen P . Mucociliary function in children with secretory otitis media. Acta Otolaryngol. 1983; 95(5-6):544-6. DOI: 10.3109/00016488309139440. View

12.

Ozkiris M, Karacavus S, Kapusuz Z, Saydam L . Comparison of two different adenoidectomy techniques with special emphasize on postoperative nasal mucociliary clearance rates: coblation technique vs. cold curettage. Int J Pediatr Otorhinolaryngol. 2012; 77(3):389-93. DOI: 10.1016/j.ijporl.2012.11.033. View

13.

Button B, Okada S, Frederick C, Thelin W, Boucher R . Mechanosensitive ATP release maintains proper mucus hydration of airways. Sci Signal. 2013; 6(279):ra46. PMC: 3791865. DOI: 10.1126/scisignal.2003755. View

14.

Li Y, Liu H, Li J, Zhang Q, Gong S, He D . Morphology and ciliary motion of mucosa in the Eustachian tube of neonatal and adult gerbils. PLoS One. 2014; 9(6):e99840. PMC: 4055728. DOI: 10.1371/journal.pone.0099840. View

15.

Martins L, Guimaraes R, Becker H, Bedran M, Medeiros M, Camargos P . Low prevalence of middle ear disease in cystic fibrosis patients. J Pediatr (Rio J). 2011; 87(1):80-3. DOI: 10.2223/JPED.2061. View

16.

SANDO I, Takahashi H, Matsune S, Aoki H . Localization of function in the eustachian tube: a hypothesis. Ann Otol Rhinol Laryngol. 1994; 103(4 Pt 1):311-4. View

17.

Proenca de Oliveira-Maul J, de Carvalho H, Goto D, Maia R, Flo C, Barnabe V . Aging, diabetes, and hypertension are associated with decreased nasal mucociliary clearance. Chest. 2012; 143(4):1091-1097. DOI: 10.1378/chest.12-1183. View

18.

Liu L, Shastry S, Byan-Parker S, Houser G, Chu K, Birket S . An autoregulatory mechanism governing mucociliary transport is sensitive to mucus load. Am J Respir Cell Mol Biol. 2014; 51(4):485-93. PMC: 4189485. DOI: 10.1165/rcmb.2013-0499MA. View

19.

Demarco R, Tamashiro E, Rossato M, Ferreira M, Valera F, Anselmo-Lima W . Ciliary ultrastructure in patients with chronic rhinosinusitis and primary ciliary dyskinesia. Eur Arch Otorhinolaryngol. 2013; 270(7):2065-70. DOI: 10.1007/s00405-012-2342-7. View

20.

Livraghi A, Randell S . Cystic fibrosis and other respiratory diseases of impaired mucus clearance. Toxicol Pathol. 2007; 35(1):116-29. DOI: 10.1080/01926230601060025. View