The Effects of Chinese Medicine on Activation of Wnt/β-Catenin Signal Pathway Under High Glucose Condition

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2015 Oct 24

PMID 26495008

Citations 4

Authors

Wei Liu

Xiaochun Liang

Dan Yang

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia and a series of complications. The Wnt/β-catenin signaling pathway is a complex protein interaction network, which is also a key regulator of cell proliferation and differentiation. Many scholars have found that high glucose can activate the Wnt signaling pathway. However, the effects of activation of this pathway in the presence of high glucose levels during the progression of diabetes still remained unclear. Here, we provide a review of the study on the effects of high glucose state on the Wnt/β-catenin signal pathway and the influence of Chinese medicine on it.

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