Non-coding Functions of Alternative Pre-mRNA Splicing in Development

Overview

Journal Semin Cell Dev Biol

Specialties Cell Biology
Reproductive Medicine

Date 2015 Oct 24

PMID 26493705

Citations 38

Authors

Stefan Mockenhaupt

Eugene V Makeyev

Affiliations

Soon will be listed here.

Abstract

A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However, alternative splicing also frequently controls output levels and spatiotemporal features of cellular and organismal gene expression programs. Here we discuss how these non-coding functions of alternative splicing contribute to development through regulation of mRNA stability, translational efficiency and cellular localization.

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