Efficacy of Olyset® Duo, a Permethrin and Pyriproxyfen Mixture Net Against Wild Pyrethroid-resistant Anopheles Gambiae S.s. from Côte D'Ivoire: an Experimental Hut Trial

Overview

Journal Parasite

Specialty Parasitology

Date 2015 Oct 23

PMID 26489480

Citations 27

Authors

Alphonsine A Koffi

Ludovic P Ahoua Alou

Armel Djenontin

Jean-Paul K Kabran

Youssouf Dosso

Aboubacar Kone

Nicolas Moiroux

Cedric Pennetier

Affiliations

Soon will be listed here.

Abstract

Pyrethroid resistance in malaria vectors has spread across sub-Saharan Africa. Alternative tools and molecules are urgently needed for effective vector control. One of the most promising strategies to prevent or delay the development of resistance is to use at least two molecules having unrelated modes of action in combination in the same bed net. We evaluated in experimental huts in Côte d'Ivoire, a new polyethylene long-lasting insecticidal net (LN) product, Olyset® Duo, incorporating permethrin (PER) and pyriproxyfen (PPF), an insect growth regulator (IGR). PPF alone or in combination with permethrin had a significant impact on fertility (7-12% reduction relative to control) and no effect on fecundity of wild multi-resistant An. gambiae s.s. These results triggered crucial research questions on the behaviour of targeted mosquitoes around the LN. To maximize the sterilizing effect of PPF in the combination, there would be a need for a trade-off between the necessary contact time of the insect with PPF and the surface content of the pyrethroid insecticide that is bioavailable and induces excito-repellency.

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