Correlation Between Apparent Diffusion Coefficients and HER2 Status in Gastric Cancers: Pilot Study

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2015 Oct 22

PMID 26487555

Citations 12

Authors

Jian He

Hua Shi

Zhuping Zhou

Jun Chen

Wenxian Guan

Hao Wang

Haiping Yu

Song Liu

Zhengyang Zhou

Xiaofeng Yang

Tian Liu

Affiliations

Soon will be listed here.

Abstract

Background: To evaluate whether apparent diffusion coefficient (ADC) value of gastric cancer obtained from diffusion weighted imaging (DWI) correlates with the HER2 status.

Methods: Forty-five patients, who had been diagnosed with gastric cancer through biopsy, were enrolled in this IRB-approved study. Each patient underwent a DWI (b values: 0 and 1,000 sec/mm(2)) prior to surgery (curative gastrectomy or palliative resection). Postoperative microscopic findings, HER2 status by immunohistochemical analysis and fluorescence in situ hybridization (FISH) were obtained. HER2 status was compared among gastric cancers with various histopathological features using the chi square test. The ADC values of gastric cancers with positive and negative HER2 were compared using the student t test.

Results: A weak yet significant correlation was observed between the mean ADC values and HER2 status (r = 0.312, P = 0.037) and scores (r = 0.419, P = 0.004). The mean ADC value of HER2-positive gastric cancers was significantly higher than those of HER2-negative tumors (1.211 vs. 0.984 mm(2)/s, P = 0.020). The minimal ADC value of HER2-positive gastric cancers was significantly higher than those of HER2-negative tumors (1.105 vs. 0.905 × 10(-3) mm(2)/s, P = 0.036).

Conclusions: In this pilot study, we have demonstrated that the ADC values of gastric cancer correlate with the HER2 status. Future research is warranted to see if DWI can predict HER2 status and help in tailoring therapy for gastric cancer.

Citing Articles

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