Oral Clindamycin Causing Acute Cholestatic Hepatitis Without Ductopenia: a Brief Review of Idiosyncratic Drug-induced Liver Injury and a Case Report

Overview

Journal J Community Hosp Intern Med Perspect

Date 2015 Oct 22

PMID 26486111

Citations 4

Authors

Harsha Moole

Zohair Ahmed

Nibha Saxena

Srinivas R Puli

Sonu Dhillon

Affiliations

Soon will be listed here.

Abstract

Clindamycin is a lincosamide antibiotic active against most of the anaerobes, protozoans, and Gram-positive bacteria, including community-acquired methicillin-resistant Staphylococcus aureus. Its use has increased greatly in the recent past due to wide spectrum of activity and good bioavailability in oral form. Close to 20% of the patients taking clindamycin experience diarrhea as the most common side effect. Hepatotoxicity is a rare side effect. Systemic clindamycin therapy has been linked to two forms of hepatotoxicity: transient serum aminotransferase elevation and an acute idiosyncratic liver injury that occurs 1-3 weeks after starting therapy. This article is a case report of oral clindamycin induced acute symptomatic cholestatic hepatitis and a brief review of the topic.

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