Immune Cell Interplay in Colorectal Cancer Prognosis

Overview

Journal World J Gastrointest Oncol

Publisher Baishideng Publishing Group

Date 2015 Oct 21

PMID 26483876

Citations 18

Authors

Samuel E Norton

Kirsten A Ward-Hartstonge

Edward S Taylor

Roslyn A Kemp

Affiliations

Soon will be listed here.

Abstract

The immune response to colorectal cancer has proven to be a reliable measure of patient outcome in several studies. However, the complexity of the immune response in this disease is not well understood, particularly the interactions between tumour-associated cells and cells of the innate and adaptive immune system. This review will discuss the relationship between cancer associated fibroblasts and macrophages, as well as between macrophages and T cells, and demonstrate how each population may support or prevent tumour growth in a different immune environment.

Citing Articles

Artificial intelligence-based analysis of tumor-infiltrating lymphocyte spatial distribution for colorectal cancer prognosis.

Cai M, Zhao K, Wu L, Huang Y, Zhao M, Hu Q Chin Med J (Engl). 2024; 137(4):421-430.

PMID: 38238158 PMC: 10876244. DOI: 10.1097/CM9.0000000000002964.

Prognostic significance of the Naples prognostic score in colorectal cancer patients undergoing curative resection: a propensity score matching analysis.

Sugimoto A, Fukuoka T, Shibutani M, Kasashima H, Kitayama K, Ohira M BMC Gastroenterol. 2023; 23(1):88.

PMID: 36966294 PMC: 10040130. DOI: 10.1186/s12876-023-02722-6.

Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer.

De Matteis R, Flak M, Gonzalez-Nunez M, Austin-Williams S, Palmas F, Colas R Sci Adv. 2022; 8(5):eabl5420.

PMID: 35108049 PMC: 8809687. DOI: 10.1126/sciadv.abl5420.

Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis.

Wang H, Tian T, Zhang J Int J Mol Sci. 2021; 22(16).

PMID: 34445193 PMC: 8395168. DOI: 10.3390/ijms22168470.

Tumor-infiltrating lymphocytes in tissue material combined with systemic lymphocyte inflammation in patients with colorectal cancer.

Jakubowska K, Koda M, Grudzinska M, Lomperta K, Famulski W Mol Clin Oncol. 2021; 14(5):97.

PMID: 33767866 PMC: 7976436. DOI: 10.3892/mco.2021.2259.

References

Devaud C, John L, Westwood J, Darcy P, Kershaw M . Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy. Oncoimmunology. 2013; 2(8):e25961. PMC: 3782527. DOI: 10.4161/onci.25961. View

Curiel T, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P . Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004; 10(9):942-9. DOI: 10.1038/nm1093. View

Salama P, Phillips M, Platell C, Iacopetta B . Low expression of Granzyme B in colorectal cancer is associated with signs of early metastastic invasion. Histopathology. 2011; 59(2):207-15. DOI: 10.1111/j.1365-2559.2011.03915.x. View

Kleinewietfeld M, Hafler D . The plasticity of human Treg and Th17 cells and its role in autoimmunity. Semin Immunol. 2013; 25(4):305-12. PMC: 3905679. DOI: 10.1016/j.smim.2013.10.009. View

Schreuders E, Ruco A, Rabeneck L, Schoen R, Sung J, Young G . Colorectal cancer screening: a global overview of existing programmes. Gut. 2015; 64(10):1637-49. DOI: 10.1136/gutjnl-2014-309086. View

Kang J, Chen J, Lee C, Chang J, Shieh Y . Intratumoral macrophage counts correlate with tumor progression in colorectal cancer. J Surg Oncol. 2010; 102(3):242-8. DOI: 10.1002/jso.21617. View

Illemann M, Bird N, Majeed A, Sehested M, Laerum O, Lund L . MMP-9 is differentially expressed in primary human colorectal adenocarcinomas and their metastases. Mol Cancer Res. 2006; 4(5):293-302. DOI: 10.1158/1541-7786.MCR-06-0003. View

Herrera M, Islam A, Herrera A, Martin P, Garcia V, Silva J . Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature. Clin Cancer Res. 2013; 19(21):5914-26. DOI: 10.1158/1078-0432.CCR-13-0694. View

Morikawa T, Baba Y, Yamauchi M, Kuchiba A, Nosho K, Shima K . STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers. Clin Cancer Res. 2011; 17(6):1452-62. PMC: 3077111. DOI: 10.1158/1078-0432.CCR-10-2694. View

10.

Chan A, Ogino S, Giovannucci E, Fuchs C . Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugs. Gastroenterology. 2010; 140(3):799-808, quiz e11. PMC: 3049858. DOI: 10.1053/j.gastro.2010.11.041. View

11.

Smith P, Smythies L, Shen R, Greenwell-Wild T, Gliozzi M, Wahl S . Intestinal macrophages and response to microbial encroachment. Mucosal Immunol. 2010; 4(1):31-42. PMC: 3821935. DOI: 10.1038/mi.2010.66. View

12.

Bonertz A, Weitz J, Pietsch D, Rahbari N, Schlude C, Ge Y . Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. J Clin Invest. 2009; 119(11):3311-21. PMC: 2769188. DOI: 10.1172/JCI39608. View

13.

Khorana A, Ryan C, Cox C, Eberly S, Sahasrabudhe D . Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with Stage II and Stage III colon carcinoma: a role for the host response in prognosis. Cancer. 2003; 97(4):960-8. DOI: 10.1002/cncr.11152. View

14.

Davies L, Jenkins S, Allen J, Taylor P . Tissue-resident macrophages. Nat Immunol. 2013; 14(10):986-95. PMC: 4045180. DOI: 10.1038/ni.2705. View

15.

Brahmer J, Tykodi S, Chow L, Hwu W, Topalian S, Hwu P . Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012; 366(26):2455-65. PMC: 3563263. DOI: 10.1056/NEJMoa1200694. View

16.

Silzle T, Kreutz M, Dobler M, Brockhoff G, Knuechel R, Kunz-Schughart L . Tumor-associated fibroblasts recruit blood monocytes into tumor tissue. Eur J Immunol. 2003; 33(5):1311-20. DOI: 10.1002/eji.200323057. View

17.

Tseng W, Leong X, Engleman E . Orthotopic mouse model of colorectal cancer. J Vis Exp. 2008; (10):484. PMC: 2557075. DOI: 10.3791/484. View

18.

Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C . Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006; 313(5795):1960-4. DOI: 10.1126/science.1129139. View

19.

Pilling D, Fan T, Huang D, Kaul B, Gomer R . Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts. PLoS One. 2009; 4(10):e7475. PMC: 2759556. DOI: 10.1371/journal.pone.0007475. View

20.

Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N . IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol. 2011; 12(3):231-8. DOI: 10.1038/ni.1990. View