Inflammatory Mechanisms of Pulmonary Injury Induced by Mustards

Overview

Journal Toxicol Lett

Publisher Elsevier

Specialty Toxicology

Date 2015 Oct 20

PMID 26478570

Citations 11

Authors

Rama Malaviya

Vasanthi R Sunil

Alessandro Venosa

Kinal N Vayas

Diane E Heck

Jeffrey D Laskin

Debra L Laskin

Affiliations

Soon will be listed here.

Abstract

Exposure of humans and animals to vesicants, including sulfur mustard (SM) and nitrogen mustard (NM), causes severe and debilitating damage to the respiratory tract. Both acute and long term pathological consequences are observed in the lung following a single exposure to these vesicants. Evidence from our laboratories and others suggest that macrophages and the inflammatory mediators they release play an important role in mustard-induced lung injury. In this paper, the pathogenic effects of SM and NM on the lung are reviewed, along with the potential role of inflammatory macrophages and mediators they release in mustard-induced pulmonary toxicity.

Citing Articles

Targeting Tumor Necrosis Factor Alpha to Mitigate Lung Injury Induced by Mustard Vesicants and Radiation.

Malaviya R, Laskin J, Businaro R, Laskin D Disaster Med Public Health Prep. 2023; 17:e553.

PMID: 37848400 PMC: 10841250. DOI: 10.1017/dmp.2023.178.

MG53 attenuates nitrogen mustard-induced acute lung injury.

Li H, Rosas L, Li Z, Bian Z, Li X, Choi K J Cell Mol Med. 2022; 26(7):1886-1895.

PMID: 35199443 PMC: 8980905. DOI: 10.1111/jcmm.16917.

Progressive Lung Injury, Inflammation, and Fibrosis in Rats Following Inhalation of Sulfur Mustard.

Malaviya R, Abramova E, Rancourt R, Sunil V, Napierala M, Weinstock D Toxicol Sci. 2020; 178(2):358-374.

PMID: 33002157 PMC: 7751178. DOI: 10.1093/toxsci/kfaa150.

Long-term Respiratory Effects of Mustard Vesicants.

Malaviya R, Laskin J, Laskin D Toxicol Lett. 2019; 319:168-174.

PMID: 31698045 PMC: 10266484. DOI: 10.1016/j.toxlet.2019.10.026.

Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard.

Sunil V, Vayas K, Abramova E, Rancourt R, Cervelli J, Malaviya R Toxicol Appl Pharmacol. 2019; 387:114798.

PMID: 31678244 PMC: 7066865. DOI: 10.1016/j.taap.2019.114798.

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