In Vivo PO2 Imaging of Tumors: Oxymetry with Very Low-Frequency Electron Paramagnetic Resonance

Overview

Journal Methods Enzymol

Specialty Biochemistry

Date 2015 Oct 20

PMID 26477263

Citations 32

Authors

Boris Epel

Howard J Halpern

Affiliations

Soon will be listed here.

Abstract

For over a century, it has been known that tumor hypoxia, regions of a tumor with low levels of oxygenation, are important contributors to tumor resistance to radiation therapy and failure of radiation treatment of cancer. Recently, using novel pulse electron paramagnetic resonance (EPR) oxygen imaging, near absolute images of the partial pressure of oxygen (pO2) in tumors of living animals have been obtained. We discuss here the means by which EPR signals can be obtained in living tissues and tumors. We review development of EPR methods to image the pO2 in tumors and the potential for the pO2 image acquisition in human subjects.

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