Alterations in Bone Marrow Metabolism Are an Early and Consistent Feature During the Development of MGUS and Multiple Myeloma

Overview

Journal Blood Cancer J

Date 2015 Oct 17

PMID 26473531

Citations 14

Authors

C Ludwig

D S Williams

D B Bartlett

S J Essex

G McNee

J W Allwood

E Jewell

A Barkhuisen

H Parry

S Anandram

P Nicolson

C Gardener

F Seymour

S Basu

W B Dunn

P A H Moss

G Pratt

D A Tennant

Affiliations

Soon will be listed here.

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References

Wang L, Chen J, Chen L, Deng P, Bu Q, Xiang P . 1H-NMR based metabonomic profiling of human esophageal cancer tissue. Mol Cancer. 2013; 12:25. PMC: 3626557. DOI: 10.1186/1476-4598-12-25. View

Lodi A, Tiziani S, Khanim F, Gunther U, Viant M, Morgan G . Proton NMR-based metabolite analyses of archived serial paired serum and urine samples from myeloma patients at different stages of disease activity identifies acetylcarnitine as a novel marker of active disease. PLoS One. 2013; 8(2):e56422. PMC: 3576408. DOI: 10.1371/journal.pone.0056422. View

Piszcz J, Lemancewicz D, Dudzik D, Ciborowski M . Differences and similarities between LC-MS derived serum fingerprints of patients with B-cell malignancies. Electrophoresis. 2013; 34(19):2857-64. View

Dubouchaud H, Butterfield G, Wolfel E, Bergman B, Brooks G . Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle. Am J Physiol Endocrinol Metab. 2000; 278(4):E571-9. DOI: 10.1152/ajpendo.2000.278.4.E571. View

Kuliszkiewicz-Janus M, Baczynski S . Chemotherapy-associated changes in 31P MRS spectra of sera from patients with multiple myeloma. NMR Biomed. 1995; 8(3):127-32. DOI: 10.1002/nbm.1940080308. View

Bonen A, McCullagh K, Putman C, Hultman E, Jones N, Heigenhauser G . Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate. Am J Physiol. 1998; 274(1):E102-7. DOI: 10.1152/ajpendo.1998.274.1.E102. View

Holmes E, Wilson I, Nicholson J . Metabolic phenotyping in health and disease. Cell. 2008; 134(5):714-7. DOI: 10.1016/j.cell.2008.08.026. View

Landgren O, Kyle R, Pfeiffer R, Katzmann J, Caporaso N, Hayes R . Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood. 2009; 113(22):5412-7. PMC: 2689042. DOI: 10.1182/blood-2008-12-194241. View

Sharma A, Tripathi M, Satyam A, Kumar L . Study of antioxidant levels in patients with multiple myeloma. Leuk Lymphoma. 2009; 50(5):809-15. DOI: 10.1080/10428190902802323. View

10.

Sonveaux P, Vegran F, Schroeder T, Wergin M, Verrax J, Rabbani Z . Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest. 2008; 118(12):3930-42. PMC: 2582933. DOI: 10.1172/JCI36843. View

11.

Ludwig C, Ward D, Martin A, Viant M, Ismail T, Johnson P . Fast targeted multidimensional NMR metabolomics of colorectal cancer. Magn Reson Chem. 2009; 47 Suppl 1:S68-73. DOI: 10.1002/mrc.2519. View

12.

Chiecchio L, Dagrada G, Ibrahim A, Dachs Cabanas E, Protheroe R, Stockley D . Timing of acquisition of deletion 13 in plasma cell dyscrasias is dependent on genetic context. Haematologica. 2009; 94(12):1708-13. PMC: 2791926. DOI: 10.3324/haematol.2009.011064. View

13.

MacIntyre D, Jimenez B, Jantus Lewintre E, Martin C, Schafer H, Ballesteros C . Serum metabolome analysis by 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups. Leukemia. 2010; 24(4):788-97. DOI: 10.1038/leu.2009.295. View

14.

Chapman M, Lawrence M, Keats J, Cibulskis K, Sougnez C, Schinzel A . Initial genome sequencing and analysis of multiple myeloma. Nature. 2011; 471(7339):467-72. PMC: 3560292. DOI: 10.1038/nature09837. View

15.

Lopez-Corral L, Sarasquete M, Bea S, Garcia-Sanz R, Mateos M, Corchete L . SNP-based mapping arrays reveal high genomic complexity in monoclonal gammopathies, from MGUS to myeloma status. Leukemia. 2012; 26(12):2521-9. DOI: 10.1038/leu.2012.128. View

16.

Puchades-Carrasco L, Lecumberri R, Martinez-Lopez J, Lahuerta J, Mateos M, Prosper F . Multiple myeloma patients have a specific serum metabolomic profile that changes after achieving complete remission. Clin Cancer Res. 2013; 19(17):4770-9. DOI: 10.1158/1078-0432.CCR-12-2917. View