How Leukocytes Cross the Vascular Endothelium

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2015 Oct 17

PMID 26471775

Citations 373

Authors

Dietmar Vestweber

Affiliations

Soon will be listed here.

Abstract

Immune responses depend on the ability of leukocytes to move from the circulation into tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow them to cross the barrier of the blood vessel wall. This process is regulated by a concerted action between endothelial cells and leukocytes, whereby endothelial cells activate leukocytes and direct them to extravasation sites, and leukocytes in turn instruct endothelial cells to open a path for transmigration. This Review focuses on recently described mechanisms that control and open exit routes for leukocytes through the endothelial barrier.

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